Document Detail


Increased lipolytic activity and high ratio of free fatty acids to albumin in sera from women with preeclampsia leads to triglyceride accumulation in cultured endothelial cells.
MedLine Citation:
PMID:  1497049     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The null hypothesis of this study was that the triglyceride accumulation in endothelial cells exposed to sera from preeclamptic women was determined by the presence of triglyceride-rich lipoproteins in the sera. STUDY DESIGN: The accumulation of triglycerides in cultured endothelial cells was studied using incorporation of tritiated glycerol. RESULTS: Triglyceride-rich lipoproteins in the patient sera contributed little to the endothelial triglyceride accumulation. However, sera from preeclamptic women were found to have a higher molar ratio of free fatty acids to albumin compared with sera from women with normal pregnancies (1.6 +/- 0.5 vs 0.9 +/- 0.4, respectively, p less than 0.025). In addition, sera from preeclamptic women, compared with sera from normal pregnancies, showed enhanced lipolytic activity (release of free fatty acids 0.85 +/- 0.29 vs 0.17 +/- 0.16 mmol/ml per 24 hours, respectively; p less than 0.025) that further increased the free fatty acids/albumin ratio. CONCLUSION: Sera from preeclamptic women have both a higher ratio of free fatty acids to albumin and increased lipolytic activity, resulting in enhanced endothelial uptake of free fatty acids, which are further esterified into triglycerides.
Authors:
M J Endresen; B Lorentzen; T Henriksen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  167     ISSN:  0002-9378     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-09-10     Completed Date:  1992-09-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  440-7     Citation Subset:  AIM; IM    
Affiliation:
Department of Obstetrics and Gynecology, Aker Hospital, Norway.
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MeSH Terms
Descriptor/Qualifier:
Cells, Cultured
Endothelium, Vascular / metabolism*,  pathology
Fatty Acids, Nonesterified / blood*
Female
Glycerol / metabolism
Hot Temperature
Humans
Lipolysis*
Lipoproteins, VLDL / pharmacology
Pre-Eclampsia / blood*
Pregnancy / blood
Reference Values
Serum Albumin / analysis*,  pharmacology
Triglycerides / metabolism*
Chemical
Reg. No./Substance:
0/Fatty Acids, Nonesterified; 0/Lipoproteins, VLDL; 0/Serum Albumin; 0/Triglycerides; 56-81-5/Glycerol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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