Document Detail


Increased lipid peroxide levels and myeloperoxidase activity in the vitreous of patients suffering from proliferative diabetic retinopathy.
MedLine Citation:
PMID:  8258399     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lipid peroxide (LPO) levels, as determined by high-performance liquid chromatography (HPLC) and by the thiobarbituric acid (TBA) method, and myeloperoxidase (MPO) activity in vitreous of patients vitrectomized because of proliferative diabetic retinopathy were compared with LPO levels and MPO activity in vitreous of patients with no vitreoretinal proliferation. Both LPO levels and MPO activity were significantly elevated in the vitreous of patients with fibrovascular vitreoretinal proliferations secondary to diabetes. The TBA method produced higher values for LPO levels than did the HPLC method. The correlation between the two methods was 0.94. Our results suggest that both oxygen-free radicals and inflammation-related reactions can participate in the pathogenesis of diabetic retinopathy.
Authors:
A J Augustin; W Breipohl; T Böker; J Lutz; M Spitznas
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie     Volume:  231     ISSN:  0721-832X     ISO Abbreviation:  Graefes Arch. Clin. Exp. Ophthalmol.     Publication Date:  1993 Nov 
Date Detail:
Created Date:  1994-01-19     Completed Date:  1994-01-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8205248     Medline TA:  Graefes Arch Clin Exp Ophthalmol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  647-50     Citation Subset:  IM    
Affiliation:
Universitäts-Augenklinik Bonn, Germany.
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MeSH Terms
Descriptor/Qualifier:
Chromatography, High Pressure Liquid
Diabetic Retinopathy / complications,  metabolism*
Eye Diseases / etiology,  metabolism
Humans
Lipid Peroxides / metabolism*
Peroxidase / metabolism*
Retinal Diseases / etiology,  metabolism
Thiobarbituric Acid Reactive Substances / metabolism
Vitreous Body / metabolism*
Chemical
Reg. No./Substance:
0/Lipid Peroxides; 0/Thiobarbituric Acid Reactive Substances; EC 1.11.1.7/Peroxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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