Document Detail


Increased levels of soluble tumour necrosis factor receptor-I (P55) and decreased IgG1 reactivities in HIV-1 patients with cytomegalovirus disease.
MedLine Citation:
PMID:  9652828     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of the study was to investigate potential associations between tumour necrosis factor (TNF), soluble TNF receptors (sTNF-Rs), immunoglobulin (Ig)G subclasses and development of cytomegalovirus (CMV) disease amongst human immunodeficiency virus (HIV)-1 patients. We enrolled HIV-1 patients with CD4 counts less than 100/microl in a prospective study and followed them over 1 year for development of CMV disease. Concentrations of TNF, sTNF-RI, sTNF-RII and IgG subclass reactivities were measured by ELISA; levels of CMV pp65 antigenaemia were determined as numbers of pp65 expressing cells/100,000 cells and were measured by staining of leucocytes; and HIV-1 RNA loads were measured by polymerase chain reaction (PCR). Eighteen patients studied with CMV disease had higher levels of sTNF-RI than 18 similar patients without CMV disease. Concentrations of sTNF-RI correlated with levels of CMV antigenaemia in blood samples collected before the development of CMV disease. Patients with CMV disease had lower levels of IgG1 reactivities to CMV than patients without CMV disease. We conclude that increased levels of sTNF-RI and decreased IgG1 reactivities are associated with an increased risk of development of CMV disease among HIV-1 patients.
Authors:
P H Jakobsen; K K Dodt; C N Meyer; T Katzenstein; J Gerstoft; P Skinhøj
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of immunology     Volume:  47     ISSN:  0300-9475     ISO Abbreviation:  Scand. J. Immunol.     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-07-30     Completed Date:  1998-07-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0323767     Medline TA:  Scand J Immunol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  591-5     Citation Subset:  IM; X    
Affiliation:
Department of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.
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MeSH Terms
Descriptor/Qualifier:
AIDS-Related Opportunistic Infections / blood,  immunology*
Adult
Antibodies, Viral / classification,  immunology*
Antigens, CD / blood*
Antigens, Viral / blood,  immunology
Cytomegalovirus Infections / blood,  complications,  immunology*
Female
Follow-Up Studies
HIV-1* / genetics
Humans
Immunoglobulin G / classification,  immunology*
Male
Middle Aged
RNA, Viral
Receptors, Tumor Necrosis Factor / blood*
Receptors, Tumor Necrosis Factor, Type I
Receptors, Tumor Necrosis Factor, Type II
Solubility
Tumor Necrosis Factor-alpha / analysis
Viral Load
Chemical
Reg. No./Substance:
0/Antibodies, Viral; 0/Antigens, CD; 0/Antigens, Viral; 0/Immunoglobulin G; 0/RNA, Viral; 0/Receptors, Tumor Necrosis Factor; 0/Receptors, Tumor Necrosis Factor, Type I; 0/Receptors, Tumor Necrosis Factor, Type II; 0/Tumor Necrosis Factor-alpha

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