Document Detail

Increased levels of prolactin during, but not after, the immunisation with rat collagen II enhances the course of arthritis in DBA/1 mice.
MedLine Citation:
PMID:  1571479     Owner:  NLM     Status:  MEDLINE    
In addition to its well known effects on reproductive organs and lactation the pituitary hormone prolactin (PRL) also influences immune functions. The present investigation was performed in order to clarify the regulatory role of prolactin in autoimmune disease by using the collagen II arthritis model. Groups of virgin female DBA/1 mice were subjected to different short-term treatment protocols (5-10 days) with rat PRL and the drugs bromocriptine (inhibits prolactin secretion) and haloperidol (enhances prolactin secretion). Treatments were performed at different stages of disease development, and effects on clinical scores, anti-collagen II antibody titres as well as agalactosyl IgG levels were recorded. The effects of the treatment protocols on serum PRL levels were assessed by using a radioimmunoassay (RIA) system. Although the accumulated results of the present study indicate that PRL does not fulfil a major role in the regulation of collagen II arthritis, some interesting observations were made. High levels of PRL (PRL injections) made the arthritis worse only if treatment was performed during the induction stage of the disease. Bromocriptine treatment during the immunisation period did not significantly affect the course of arthritis, but treatment at later stages tended to cause exacerbation (significant at the onset period only). These results indicate that PRL has different effects during early and late stages of the development of collagen II-induced arthritis.
R Mattsson; A Mattsson; I Hansson; R Holmdahl; G A Rook; A Whyte
Related Documents :
3135849 - Prolactin in patients with major depressive disorder and in healthy subjects. iii. inve...
6417219 - Effects of pharmacological doses of testosterone and dihydrotestosterone on the hypotha...
16626919 - Seasonal and photoperiodic regulation of secretion of hormones associated with reproduc...
263659 - Neurogenic galactorrhea-amenorrhea.
3491019 - Synthesis and storage of prolactin in the pituitary gland of bullfrog tadpoles during m...
1752829 - Exogenous opioids increase plasma prolactin in holstein calves primarily via a dopamine...
1373609 - Lipopolysaccharide and serum cause the translocation of g-protein to the membrane and p...
111939 - Serum kinetics of doxycycline polyphosphate in dogs.
10835489 - Effects of three-month oral supplementation of beta-carotene and vitamin c on serum con...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Autoimmunity     Volume:  11     ISSN:  0891-6934     ISO Abbreviation:  Autoimmunity     Publication Date:  1992  
Date Detail:
Created Date:  1992-06-01     Completed Date:  1992-06-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8900070     Medline TA:  Autoimmunity     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  163-70     Citation Subset:  IM    
Department of Molecular Physiology, AFRC Institute of Animal Physiology and Genetics Research, Bab'aham, Cambridge, U.K.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Arthritis / blood*,  chemically induced,  immunology
Bromocriptine / pharmacology
Collagen / immunology,  toxicity*
Haloperidol / pharmacology
Mice, Inbred DBA
Prolactin / blood*
T-Lymphocytes / immunology
Reg. No./Substance:
25614-03-3/Bromocriptine; 52-86-8/Haloperidol; 9002-62-4/Prolactin; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Myasthenia gravis with thymoma is not associated with an increased incidence of non-muscle autoimmun...
Next Document:  Immunopurification and characterization of thyroid autoantibodies with dual specificity for thyroglo...