| Increased levels of monocyte-related cytokines in patients with unstable angina. | |
| | |
MedLine Citation:
|
PMID: 11888524 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Inflammatory cytokines play important roles in coronary artery disease. We investigated the clinical significance of monocyte-related cytokine expression in patients with angina pectoris. We studied 26 patients with stable effort angina and 20 patients with unstable angina in whom stenotic lesions of the coronary arteries were confirmed by selective coronary angiography. Plasma levels of interleukin-6 (IL-6), macrophage colony stimulating factor (MCSF), and monocyte chemoattractant protein-1 (MCP-1) were measured. Plasma levels of IL-6, MCSF, and MCP-1 in patients with unstable angina were significantly higher than those in patients with stable angina or control subjects. Patients with unstable angina were further divided into sub-groups according to their clinical classification; Levels of IL-6, MCSF, and MCP-1 in patients, who had anginal attacks at rest within the 48 h prior to admission (Braunwald class IIIB) were significantly higher than those in patients, who did not have attacks at rest (class IB). Five unstable patients, who were refractory to medical therapy and were referred for emergency coronary revascularization showed marked elevation of plasma MCSF and MCP-1 levels. In conclusion, plasma levels of monocyte-related cytokines were elevated in unstable angina. These increases were marked in patients with unstable angina with recent ischemic attack at rest, suggesting that activation of monocytes is involved in vulnerability of underlying atheromatous plaque. |
| | |
Authors:
|
Yukihiro Hojo; Uichi Ikeda; Masafumi Takahashi; Kazuyuki Shimada |
Related Documents
:
|
2784024 - Angiographic and clinical characteristics of patients with unstable angina showing an e... 8049984 - Angiographic findings of silent ischaemia following aortocoronary bypass surgery. 11092644 - Impact of social support, cynical hostility and anger expression on progression of coro... 10149104 - Coronary angioplasty in patients who were considered poor bypass surgery candidates. 22612914 - Right atrial remodeling is more advanced in patients with atrial flutter than with atri... 23423474 - Comparison of the clinical characteristics of patients with small bowel and gastric ani... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Atherosclerosis Volume: 161 ISSN: 0021-9150 ISO Abbreviation: Atherosclerosis Publication Date: 2002 Apr |
Date Detail:
|
Created Date: 2002-03-12 Completed Date: 2002-05-14 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
|
Languages: eng Pagination: 403-8 Citation Subset: IM |
Affiliation:
|
Department of Cardiology, Jichi Medical School, Minamikawachi-machi, Tochigi 329-0498, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Analysis of Variance Angina, Unstable / blood*, physiopathology* Biological Markers / blood Chemokine CCL2 / analysis Cytokines / analysis*, biosynthesis* Enzyme-Linked Immunosorbent Assay Female Heart Catheterization Humans Interleukin-6 / analysis Macrophage Colony-Stimulating Factor / analysis Male Middle Aged Monocytes / metabolism* Probability Prognosis Prospective Studies Sensitivity and Specificity Severity of Illness Index |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Chemokine CCL2; 0/Cytokines; 0/Interleukin-6; 81627-83-0/Macrophage Colony-Stimulating Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Beneficial effects of blood donation on high density lipoprotein concentration and the oxidative pot...
Next Document: Effects of menopause on intraindividual changes in serum lipids, blood pressure, and body weight--th...