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INCREASED LEVELS OF MODIFIED ADVANCED OXIDATION PROTEIN PRODUCTS ARE ASSOCIATED WITH CENTRAL AND PERIPHERAL BLOOD PRESSURE IN PERITONEAL DIALYSIS PATIENTS.
MedLine Citation:
PMID:  24584606     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Background and aims: Oxidative stress plays an important role in the pathogenesis of cardiovascular disease (CVD). Central blood pressure (BP) is thought to be more relevant than peripheral BP for the pathogenesis of CVD. Advanced oxidation protein products (AOPP) are markers of oxidative stress. This study investigated the relationship between AOPP and central BP in peritoneal dialysis (PD) patients. ♢ METHODS: In a cross-sectional study of 75 PD patients (67% men), we analyzed two oxidative stress markers, AOPP (modified assay, mAOPP, correcting for the impact of triglycerides) and pentosidine, three inflammation markers, interleukin-6 (IL-6), tumor necrosis factor (TNF), and high-sensitivity C-reactive protein (hs-CRP). All patients underwent measurement of central systolic blood pressure (SBP) and diastolic blood pressure (DBP) by applanation tonometry. ♢ RESULTS: Patients with mAOPP levels above the median had a higher central SBP and DBP than those below the median values. In univariate analysis, the levels of mAOPP associated with central SBP and central DBP. Multiple regression analysis, adjusting for age, gender, diabetes, CVD, protein-energy wasting (PEW), hs-CRP and extracellular water by multi-frequency bioimpedance or N-terminal prohormone of brain natriuretic peptide (NT-proBNP), confirmed independent associations between mAOPP and central SBP and central DBP respectively. ♢ CONCLUSIONS: The mAOPP level is independently associated with the central SBP and DBP in PD patients. This finding suggests that oxidative stress may be involved in the pathogenesis of hypertension or that hypertension itself or factors associated with hypertension such as fluid overload may have an additional effect on oxidative stress in PD patients.
Authors:
Hong Xu; Ivan Cabezas-Rodriguez; Abdul Rashid Qureshi; Olof Heimburger; Peter Barany; Sunna Snaedal; Björn Anderstam; Ann-Christin Bragfors Helin; Juan J Carrero; Peter Stenvinkel; Bengt Lindholm
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-3-1
Journal Detail:
Title:  Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis     Volume:  -     ISSN:  1718-4304     ISO Abbreviation:  Perit Dial Int     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-3-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8904033     Medline TA:  Perit Dial Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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