Document Detail

Increased levels of macrophage colony-stimulating factor, gamma interferon, and tumor necrosis factor alpha in sera of patients with Orientia tsutsugamushi infection.
MedLine Citation:
PMID:  9399546     Owner:  NLM     Status:  MEDLINE    
Levels of macrophage colony-stimulating factor (nine of nine patients) and gamma interferon (six of nine patients) in serum were elevated above the range of normal in the acute phase of tsutsugamushi disease. Significant increases in levels of tumor necrosis factor alpha were observed during the convalescent phase in five patients, and they exceeded the levels observed during the acute phase. Hypercytokinemia appeared to be responsible for the emergence of the symptoms of tsutsugamushi disease.
H Iwasaki; N Takada; T Nakamura; T Ueda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical microbiology     Volume:  35     ISSN:  0095-1137     ISO Abbreviation:  J. Clin. Microbiol.     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-02-05     Completed Date:  1998-02-05     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505564     Medline TA:  J Clin Microbiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3320-2     Citation Subset:  IM    
First Department of Internal Medicine, Fukui Medical School, Matsuoka, Japan.
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MeSH Terms
Acute Disease
Aged, 80 and over
Granulocyte Colony-Stimulating Factor / blood
Interferon-gamma / blood*
Macrophage Colony-Stimulating Factor / blood*
Middle Aged
Scrub Typhus / blood*,  etiology,  immunology*
Time Factors
Tumor Necrosis Factor-alpha / metabolism*
Reg. No./Substance:
0/Tumor Necrosis Factor-alpha; 143011-72-7/Granulocyte Colony-Stimulating Factor; 81627-83-0/Macrophage Colony-Stimulating Factor; 82115-62-6/Interferon-gamma

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