| Increased levels of lipid oxidation products in low density lipoproteins of patients suffering from rheumatoid arthritis. | |
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MedLine Citation:
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PMID: 9219348 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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9-Hydroxy-10,12-octadecadienoic acid (9-HODE) and 13-hydroxy-9,11-octadecadienoic acid (13-HODE) are accumulated in the low density lipoproteins of patients suffering from rheumatoid arthritis for a factor of 20-50 compared to healthy individuals of the same age. Both acids, derived by lipid peroxidation of linoleic acid, induce the release of interleukin 1 beta. The latter induces bone degression. The genesis of 9- and 13-HODE seems therefore to be an important factor in the development and progression of rheuma; in addition 9-HODE was reported to be a stimulus of inflammation, comparable to leukotrienes. |
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Authors:
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W Jira; G Spiteller; A Richter |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Chemistry and physics of lipids Volume: 87 ISSN: 0009-3084 ISO Abbreviation: Chem. Phys. Lipids Publication Date: 1997 May |
Date Detail:
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Created Date: 1997-08-06 Completed Date: 1997-08-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0067206 Medline TA: Chem Phys Lipids Country: IRELAND |
Other Details:
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Languages: eng Pagination: 81-9 Citation Subset: IM |
Affiliation:
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Lehrstuhl für Organische Chemie I, Universität Bayreuth, NW I, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aldehydes / blood Arthritis, Rheumatoid / blood* Chromatography, Gas Female Humans Linoleic Acid Linoleic Acids / blood Linoleic Acids, Conjugated* Lipid Peroxidation* Lipid Peroxides / blood Lipoproteins, LDL / blood*, chemistry Male Mass Spectrometry Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Aldehydes; 0/Linoleic Acids; 0/Linoleic Acids, Conjugated; 0/Lipid Peroxides; 0/Lipoproteins, LDL; 15514-85-9/9-hydroxy-10,12-octadecadienoic acid; 17046-02-5/2-hydroxyheptanal; 2197-37-7/Linoleic Acid; 5204-88-6/13-hydroxy-9,11-octadecadienoic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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