Document Detail


Increased levels of lipid oxidation products in low density lipoproteins of patients suffering from rheumatoid arthritis.
MedLine Citation:
PMID:  9219348     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
9-Hydroxy-10,12-octadecadienoic acid (9-HODE) and 13-hydroxy-9,11-octadecadienoic acid (13-HODE) are accumulated in the low density lipoproteins of patients suffering from rheumatoid arthritis for a factor of 20-50 compared to healthy individuals of the same age. Both acids, derived by lipid peroxidation of linoleic acid, induce the release of interleukin 1 beta. The latter induces bone degression. The genesis of 9- and 13-HODE seems therefore to be an important factor in the development and progression of rheuma; in addition 9-HODE was reported to be a stimulus of inflammation, comparable to leukotrienes.
Authors:
W Jira; G Spiteller; A Richter
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chemistry and physics of lipids     Volume:  87     ISSN:  0009-3084     ISO Abbreviation:  Chem. Phys. Lipids     Publication Date:  1997 May 
Date Detail:
Created Date:  1997-08-06     Completed Date:  1997-08-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0067206     Medline TA:  Chem Phys Lipids     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  81-9     Citation Subset:  IM    
Affiliation:
Lehrstuhl für Organische Chemie I, Universität Bayreuth, NW I, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aldehydes / blood
Arthritis, Rheumatoid / blood*
Chromatography, Gas
Female
Humans
Linoleic Acid
Linoleic Acids / blood
Linoleic Acids, Conjugated*
Lipid Peroxidation*
Lipid Peroxides / blood
Lipoproteins, LDL / blood*,  chemistry
Male
Mass Spectrometry
Middle Aged
Chemical
Reg. No./Substance:
0/Aldehydes; 0/Linoleic Acids; 0/Linoleic Acids, Conjugated; 0/Lipid Peroxides; 0/Lipoproteins, LDL; 15514-85-9/9-hydroxy-10,12-octadecadienoic acid; 17046-02-5/2-hydroxyheptanal; 2197-37-7/Linoleic Acid; 5204-88-6/13-hydroxy-9,11-octadecadienoic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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