| Increased levels of lead in the blood and frequencies of lymphocytic micronucleated binucleated cells among workers from an electronic-waste recycling site. | |
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MedLine Citation:
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PMID: 21547822 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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In recent years, adverse health effects of chemicals from electronic waste (e-waste) have been reported. However, little is known about the genotoxic effects of chemicals in e-waste. In the present study, air concentrations of the toxic metals at e-waste and control sites were analyzed using inductively-coupled plasma mass spectrometry. Levels of toxic metals (lead, copper and cadmium) in blood and urine were detected using atomic absorption spectrophotometry in 48 exposed individuals and 56 age- and sex-matched controls. The frequencies of lymphocytic micronucleated binucleated cells (MNBNCs) were determined using a cytokinesis-block micronucleus assay. Results indicated that blood lead levels were significantly higher in the exposed group (median: 11.449 μg/dL, 1st/3rd quartiles: 9.351-14.410 μg/dL) than in the control group (median: 9.104 μg/dL, 1st/3rd quartiles: 7.275-11.389 μg/dL). The exposed group had higher MNBNCs frequencies (median: 4.0ˆ, 1st/3rd quartiles: 2.0-7.0ˆ) compared with the controls (median: 1.0ˆ, 1st/3rd quartiles: 0.0-2.0ˆ). Additionally, MNBNCs frequencies and blood lead levels were positively correlated (r = 0.254, p<0.01). Further analysis suggested that a history of working with e-waste was a predictor for increased blood lead levels and MNBNCs frequencies in the subjects. The results suggest that both the living and occupational environments at the e-waste site may be risk factors for increased MNBNCs frequencies among those who are exposed. |
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Authors:
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Qian Wang; An M He; Bo Gao; Lan Chen; Qiang Z Yu; Huan Guo; Bin J Shi; Pu Jiang; Zeng Y Zhang; Ping L Li; Ying G Sheng; Mo J Fu; Chun T Wu; Min X Chen; Jing Yuan |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of environmental science and health. Part A, Toxic/hazardous substances & environmental engineering Volume: 46 ISSN: 1532-4117 ISO Abbreviation: J Environ Sci Health A Tox Hazard Subst Environ Eng Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9812551 Medline TA: J Environ Sci Health A Tox Hazard Subst Environ Eng Country: England |
Other Details:
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Languages: eng Pagination: 669-76 Citation Subset: IM |
Affiliation:
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Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P. R. China. |
Export Citation:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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