| Increased levels of interleukin-6 in cervical secretions and assessment of the uterine cervix by transvaginal ultrasonography predict preterm premature rupture of the membranes. | |
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MedLine Citation:
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PMID: 12576744 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The objective of this study was to investigate the predictive factors of premature rupture of the membranes (preterm PROM). METHODS: The study was undertaken with cervical secretions collected from 72 consenting singleton pregnant women between 20 and 33 weeks of gestation. The levels of interleukin (IL) 1alpha, IL-1beta, IL-6, IL-8, matrix metalloproteinase (MMP) 1, MMP-2, MMP-9, tissue inhibitors of matrix metalloproteinase (TIMP) 1, TIMP-2, granulocyte elastase, and fetal fibronectin in cervical diluted specimens were measured by immunoassay, and the uterine cervix was assessed by transvaginal ultrasonography. Demographic, obstetric, clinical, neonatal, and laboratory data were analyzed by univariate analysis, multiple logistic regression, and receiver operator characteristic curve analysis. RESULTS: Preterm PROM occurred in 6 women, and 63 women delivered at term. Multiple logistic regression analysis indicated a significant independent association with preterm PROM for the cervical IL-6 levels and cervical length. The receiver operator characteristic curve analysis revealed that an IL-6 level of >/=240 pg/ml in cervical secretions and a cervical length of </=28 mm had higher diagnostic performance in predicting preterm PROM. CONCLUSION: It is suggested that preterm PROM is associated with increased cervical IL-6 levels and a short cervix. |
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Authors:
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Tatsuro Kishida; Hideto Yamada; Itsuko Furuta; Noriko Kobayashi; Emi K Hirayama; Yasuhiko Ebina; Noriaki Sakuragi; Seiichiro Fujimoto |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Fetal diagnosis and therapy Volume: 18 ISSN: 1015-3837 ISO Abbreviation: Fetal. Diagn. Ther. Publication Date: 2003 Mar-Apr |
Date Detail:
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Created Date: 2003-02-10 Completed Date: 2003-09-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9107463 Medline TA: Fetal Diagn Ther Country: Switzerland |
Other Details:
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Languages: eng Pagination: 98-104 Citation Subset: IM |
Copyright Information:
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Copyright 2003 S. Karger AG, Basel |
Affiliation:
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Department of Obstetrics and Gynecology, Hokkaido University School of Medicine, Sapporo, Japan. tatsuro@mail.med.upenn.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cervix Uteri / metabolism, secretion*, ultrasonography* Female Humans Infant, Newborn Interleukin-6 / metabolism, secretion* Logistic Models Obstetric Labor, Premature / metabolism, ultrasonography* Predictive Value of Tests Pregnancy Statistics, Nonparametric Vagina / ultrasonography* |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-6 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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