Document Detail

Increased levels of extracellular noradrenaline in the frontal cortex of rats exposed to naturalistic environmental stimuli: modulation by acute systemic administration of diazepam or buspirone.
MedLine Citation:
PMID:  8880943     Owner:  NLM     Status:  MEDLINE    
In vivo microdialysis was used to investigate the effects of an IP injection of diazepam or buspirone (each at 3 mg/kg) on spontaneous efflux of noradrenaline in rat frontal cortex, and on changes in efflux induced by naturalistic stress. After drug administration, rats either remained in their home cages or were transferred individually to a novel cage, 1 h later. The novel cage was brightly lit (1500 lux) and contained another, unfamiliar rat. After transfer to the novel cage, noradrenaline efflux was lower in diazepam-injected rats than in their vehicle-injected counterparts. However, in both cases, stress caused a significant increase in efflux and the net increase was not affected by diazepam. Similarly, buspirone, which increased spontaneous efflux of noradrenaline, did not affect the net increase in efflux during stress. Neither compound modified locomotor activity in the novel cage. This suggests that any changes in noradrenaline efflux are unrelated to drug effects on non-specific arousal. It is concluded that generically unrelated anxiolytic agents can have different effects on spontaneous efflux of noradrenaline but do not modify the noradrenergic response to naturalistic stimuli.
J W Dalley; K Mason; S C Stanford
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Psychopharmacology     Volume:  127     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  1996 Sep 
Date Detail:
Created Date:  1997-01-10     Completed Date:  1997-01-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  47-54     Citation Subset:  IM    
Department of Pharmacology, University College London, UK.
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MeSH Terms
Anti-Anxiety Agents / pharmacology*
Buspirone / pharmacology*
Diazepam / pharmacology*
Frontal Lobe / chemistry*,  drug effects,  physiology
Housing, Animal
Motor Activity / drug effects
Norepinephrine / analysis*,  physiology
Rats, Sprague-Dawley
Stress, Psychological / drug therapy,  physiopathology*
Reg. No./Substance:
0/Anti-Anxiety Agents; 36505-84-7/Buspirone; 439-14-5/Diazepam; 51-41-2/Norepinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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