| Increased levels of circulating interleukin-8 in patients with large burns: relation to burn size and sepsis. | |
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MedLine Citation:
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PMID: 7473946 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Large burns are followed by significant trauma-induced immunomodulation, and activated neutrophils can be demonstrated in the circulation of burn patients shortly after injury. Interleukin-8 (IL-8) is a recently described molecule with neutrophil activating properties and in the present study we have measured the concentration of this cytokine in plasma from 27 patients with large burns during hospitalization using an enzyme linked immunosorbent assay (ELISA). The mean patient plasma concentration of IL-8 at admission was about 60 times higher than that of healthy controls. Furthermore, patients with total body surface area burn of more than 40% had significantly higher IL-8 concentrations in plasma than patients with smaller burns. For patients without serious infectious complications, the IL-8 concentration fell gradually after injury, whereas in patients with complicating sepsis a second peak of IL-8 was demonstrated. Thus, the increased IL-8 concentrations seem to be related to burn size and to have a role in the pathophysiology of sepsis in patients with large burns. The large amounts of circulating IL-8 following thermal injury may contribute to the strong and sustained activation of neutrophils reported earlier in patients with large burns. |
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Authors:
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H Vindenes; E Ulvestad; R Bjerknes |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of trauma Volume: 39 ISSN: 0022-5282 ISO Abbreviation: J Trauma Publication Date: 1995 Oct |
Date Detail:
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Created Date: 1995-12-07 Completed Date: 1995-12-07 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0376373 Medline TA: J Trauma Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 635-40 Citation Subset: AIM; IM |
Affiliation:
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Department of Plastic Surgery, University of Bergen, Haukeland Hospital, Norway. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Body Surface Area Burns / complications, immunology* Case-Control Studies Enzyme-Linked Immunosorbent Assay Female Follow-Up Studies Humans Interleukin-8 / blood* Leukocyte Count Male Middle Aged Neutrophil Activation / immunology Sepsis / etiology*, immunology Trauma Severity Indices |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-8 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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