Document Detail


Increased levels of apo-transcobalamins I and II in amniotic fluid from pregnant women with previous neural tube defect offspring.
MedLine Citation:
PMID:  2430743     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In an attempt to identify biochemical components of the genetic predisposition to neural tube defects (NTDs), levels of folate, cobalamin, apo-transcobalamins I and II and alpha-fetoprotein were studied in midtrimester amniotic fluid from 24 pregnant women who had previously had a child with NTD. The control group consisted of 76 mothers, subjected to amniocentesis for reasons other than risk of NTD in offspring. Only pregnancies with normal outcome were included. No differences were found between groups for levels of folate, cobalamin or alpha-fetoprotein. Folate intake or metabolism did not appear to differ between groups. In contrast, the level of apo-transcobalamin I was doubled and the level of apo-transcobalamin II tripled in amniotic fluid from women who had had a child with NTD compared with the control group. Since the variation in apo-transcobalamin II in adults is to a high degree genetically determined, the present results may suggest that the genetic predisposition to NTD is associated with variation in this protein. Further studies are needed to substantiate or reject this possibility.
Authors:
P Magnus; E M Magnus; K Berg
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical genetics     Volume:  30     ISSN:  0009-9163     ISO Abbreviation:  Clin. Genet.     Publication Date:  1986 Sep 
Date Detail:
Created Date:  1987-01-22     Completed Date:  1987-01-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0253664     Medline TA:  Clin Genet     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  167-72     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Amniotic Fluid / metabolism*
Apoproteins / genetics,  metabolism
Female
Folic Acid / metabolism
Humans
Neural Tube Defects / genetics,  metabolism*
Pregnancy
Transcobalamins / genetics,  metabolism*
Vitamin B 12 / metabolism
alpha-Fetoproteins / metabolism
Chemical
Reg. No./Substance:
0/Apoproteins; 0/Transcobalamins; 0/alpha-Fetoproteins; 59-30-3/Folic Acid; 68-19-9/Vitamin B 12

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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