| Increased levels of APRIL (a proliferation-inducing ligand) mRNA in multiple sclerosis. | |
| | |
MedLine Citation:
|
PMID: 16087247 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
B cells play an indispensable, yet indeterminate, role in the pathogenesis of multiple sclerosis (MS). We measured mRNA of APRIL-a promotor of B-cell survival-in peripheral blood and quantified protein levels in plasma and cerebrospinal fluid in MS patients and controls. APRIL mRNA levels in monocytes and T cells were significantly higher in MS patients than in controls. Levels of soluble APRIL in plasma were higher in patients with chronic progressive MS than in patients with relapsing-remitting MS, albeit not significantly. MS may thus be associated with increased transcription in peripheral blood of factors promoting B-cell survival, including APRIL. |
| | |
Authors:
|
Mathula Thangarajh; Thomas Masterman; Uros Rot; Kristina Duvefelt; Boel Brynedal; Virginija Danylaité Karrenbauer; Jan Hillert |
Related Documents
:
|
203087 - The incidence of antiviral antibodies in multiple slcerosis. 15533657 - Dystonia in a 13-year-old boy with secondary progressive multiple sclerosis. 3457897 - A study of histocompatibility antigens in patients with motor neuron disease in the nor... 19177 - The activity of gamma-glutamyl transferase in the serum of multiple sclerosis and other... 6850827 - Unsuspected vascular disease: a potential limitation to the use of the intra-aortic bal... 895307 - Secondary phase nystagmus--revisited. |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of neuroimmunology Volume: 167 ISSN: 0165-5728 ISO Abbreviation: J. Neuroimmunol. Publication Date: 2005 Oct |
Date Detail:
|
Created Date: 2005-09-05 Completed Date: 2005-11-21 Revised Date: 2008-05-14 |
Medline Journal Info:
|
Nlm Unique ID: 8109498 Medline TA: J Neuroimmunol Country: Netherlands |
Other Details:
|
Languages: eng Pagination: 210-4 Citation Subset: IM |
Affiliation:
|
Division of Neurology, Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital, SE-141 86 Stockholm, Sweden. Mathula.Thangarajh@neurotec.ki.se |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged B-Lymphocytes / metabolism Blotting, Western / methods Cell Count / methods Child Child, Preschool Female Gene Expression Regulation / physiology* Humans Infant Infant, Newborn Leukocytes / metabolism Male Membrane Proteins / blood*, cerebrospinal fluid*, genetics Middle Aged Multiple Sclerosis / classification, genetics, metabolism* RNA, Messenger / metabolism Reverse Transcriptase Polymerase Chain Reaction / methods Tumor Necrosis Factor Ligand Superfamily Member 13 Tumor Necrosis Factor-alpha / cerebrospinal fluid*, genetics X-Linked Inhibitor of Apoptosis Protein / genetics, metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Membrane Proteins; 0/RNA, Messenger; 0/TNFSF13 protein, human; 0/Tumor Necrosis Factor Ligand Superfamily Member 13; 0/Tumor Necrosis Factor-alpha; 0/X-Linked Inhibitor of Apoptosis Protein; 0/XIAP protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Functional expression of CCL6 by rat microglia: a possible role of CCL6 in cell-cell communication.
Next Document: Determining genetic stabilities of chimeric dengue vaccine candidates based on dengue 2 PDK-53 virus...