Document Detail


Increased levels of APRIL (a proliferation-inducing ligand) mRNA in multiple sclerosis.
MedLine Citation:
PMID:  16087247     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
B cells play an indispensable, yet indeterminate, role in the pathogenesis of multiple sclerosis (MS). We measured mRNA of APRIL-a promotor of B-cell survival-in peripheral blood and quantified protein levels in plasma and cerebrospinal fluid in MS patients and controls. APRIL mRNA levels in monocytes and T cells were significantly higher in MS patients than in controls. Levels of soluble APRIL in plasma were higher in patients with chronic progressive MS than in patients with relapsing-remitting MS, albeit not significantly. MS may thus be associated with increased transcription in peripheral blood of factors promoting B-cell survival, including APRIL.
Authors:
Mathula Thangarajh; Thomas Masterman; Uros Rot; Kristina Duvefelt; Boel Brynedal; Virginija Danylaité Karrenbauer; Jan Hillert
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  167     ISSN:  0165-5728     ISO Abbreviation:  J. Neuroimmunol.     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2005-09-05     Completed Date:  2005-11-21     Revised Date:  2008-05-14    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  210-4     Citation Subset:  IM    
Affiliation:
Division of Neurology, Department of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital, SE-141 86 Stockholm, Sweden. Mathula.Thangarajh@neurotec.ki.se
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
B-Lymphocytes / metabolism
Blotting, Western / methods
Cell Count / methods
Child
Child, Preschool
Female
Gene Expression Regulation / physiology*
Humans
Infant
Infant, Newborn
Leukocytes / metabolism
Male
Membrane Proteins / blood*,  cerebrospinal fluid*,  genetics
Middle Aged
Multiple Sclerosis / classification,  genetics,  metabolism*
RNA, Messenger / metabolism
Reverse Transcriptase Polymerase Chain Reaction / methods
Tumor Necrosis Factor Ligand Superfamily Member 13
Tumor Necrosis Factor-alpha / cerebrospinal fluid*,  genetics
X-Linked Inhibitor of Apoptosis Protein / genetics,  metabolism
Chemical
Reg. No./Substance:
0/Membrane Proteins; 0/RNA, Messenger; 0/TNFSF13 protein, human; 0/Tumor Necrosis Factor Ligand Superfamily Member 13; 0/Tumor Necrosis Factor-alpha; 0/X-Linked Inhibitor of Apoptosis Protein; 0/XIAP protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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