Document Detail

Increased level of second trimester maternal serum chorionic gonadotropin in pregnancy with a fetus affected by homozygous alpha-thalassemia 1.
MedLine Citation:
PMID:  7979563     Owner:  NLM     Status:  MEDLINE    
With enzyme immunoassay, maternal serum chorionic gonadotropin (MShCG) level was determined in 58 pregnancies affected with fetal homozygous alpha-thalassemia 1. In 40 pregnancies with a gestational age of 10 to 14 weeks, 8 (20%) had an MShCG level above 2.5 multiples of the median (MoM); while in the other 18 pregnancies with a gestational age of 15 to 23 weeks, 14 (78%) had a level above 2.5 MoMs and none had a level below the median. Homozygous alpha-thalassemia 1 of the fetus was associated with an elevated MShCG. Therefore in second-trimester screening for Down's syndrome by measurement of MShCG, homozygous alpha-thalassemia 1 should also be considered if elevated MShCG levels are found.
L H Tseng; H L Hwa; S M Chuang; T Y Lee; T M Ko
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of gynecology and obstetrics     Volume:  255     ISSN:  0932-0067     ISO Abbreviation:  Arch. Gynecol. Obstet.     Publication Date:  1994  
Date Detail:
Created Date:  1994-12-20     Completed Date:  1994-12-20     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8710213     Medline TA:  Arch Gynecol Obstet     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  113-7     Citation Subset:  IM    
Department of Medical Genetics, College of Medicine, National Taiwan University, Taipei, Republic of China.
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MeSH Terms
Chorionic Gonadotropin / blood*
Genetic Testing
Infant, Newborn
Pregnancy Trimester, Second
Prenatal Diagnosis*
Risk Factors
alpha-Thalassemia / blood,  diagnosis,  genetics*
Reg. No./Substance:
0/Chorionic Gonadotropin

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