Document Detail

Increased leukocyte adhesiveness/aggregation in patients with inflammatory bowel disease during remission. Further evidence for subclinical inflammation.
MedLine Citation:
PMID:  8646948     Owner:  NLM     Status:  MEDLINE    
PURPOSE: We have used a novel leukocyte adhesiveness/aggregation test (LAAT) to show that many patients with inflammatory bowel disease (IBD) in clinical remission have a subclinical low grade inflammation. METHODS: Included in the study are 500 controls, 96 patients with IBD in remission, and 106 patients in relapse. RESULTS: The percent of aggregated white blood cells detected in the peripheral blood was 5.9 +/- 3.9, 9.1 +/- 5.9, and 18.8 +/- 9.4, respectively. The difference between each group and any other was significant at P < 0.0001. Similar results were obtained when other acute phase reactants like the erythrocyte sedimentation rate, white blood cell count, differential count, and C-reactive protein level were examined. However, in a linear regression analysis, LAAT was the only significant (P < 0.0006) variable that could classify correctly each subject to the appropriate category of control and IBD in remission or relapse. CONCLUSIONS: Identification of patients with IBD in clinical remission who have ongoing inflammation may be of clinical-therapeutic relevance. The LAAT is a simple, rapid, and convenient test. The present study indicates that it is also very sensitive.
N Arber; A Hallak; I Dotan; Y Bujanover; E Liberman; M Santo; M Moshkowitz; E Tiomny; M Aronson; S Berliner; T Gilat
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Diseases of the colon and rectum     Volume:  39     ISSN:  0012-3706     ISO Abbreviation:  Dis. Colon Rectum     Publication Date:  1996 Jun 
Date Detail:
Created Date:  1996-07-19     Completed Date:  1996-07-19     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372764     Medline TA:  Dis Colon Rectum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  632-5     Citation Subset:  IM    
Department of Gastroenterology, Tel-Aviv Medical Center Ichilov Hospital, Sackler Faculty of Medicine, Tel-Aviv University, Israel.
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MeSH Terms
Aged, 80 and over
Biological Markers
Blood Sedimentation
C-Reactive Protein / chemistry
Case-Control Studies
Inflammatory Bowel Diseases / blood,  immunology*
Leukocyte Adherence Inhibition Test / methods*
Leukocyte Count
Linear Models
Middle Aged
Remission Induction
Sensitivity and Specificity
Severity of Illness Index
Reg. No./Substance:
0/Biological Markers; 9007-41-4/C-Reactive Protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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