| Increased leukocyte aggregates are associated with atherosclerosis in patients with hemodialysis. | |
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MedLine Citation:
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PMID: 19583603 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Little data are available on the role of blood rheology in atherosclerosis in hemodialysis (HD) patients. This study sought to assess the relationship between leukocytes conjugated with platelets (leukocyte aggregates [LA]) and atherosclerosis in patients with HD. The present study included 118 patients on HD. As surrogate markers of atherosclerosis, aortic stiffness measured by brachial-ankle pulse wave velocity, and carotid intima-media thickness (IMT) were measured. As an assessment of LA, a method, microchannel array flow analyzer, which makes it possible to directly observe the flow of blood cell elements through the microchannel, was used. We measured a number of LA during 50 microL flow of whole blood through microchannels. In 12 age-matched healthy individuals, a number of LA during 50 microL flow of whole blood was 25.7+/-5.4, whereas in HD patients it was significantly increased up to 48.2+/-16.4 (P<0.001). Flow cytometry demonstrated that LA were predominantly monocytes. Leukocyte aggregates were positively associated with plasma levels of fibrinogen (P<0.01), or serum high-sensitive C-reactive protein (P<0.01). Moreover, LA had highly significant associations with brachial-ankle pulse wave velocity (P<0.001) and IMT (P<0.001). In conclusion, we demonstrated hemorheologically that monocyte-platelet conjugates play an important role in aortic stiffness and IMT in HD patients. |
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Authors:
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Shuzo Kobayashi; Mitsuko Miyamoto; Hajime Kurumatani; Machiko Oka; Kyoko Maesato; Tsutomu Mano; Ryota Ikee; Hidekazu Moriya; Takayasu Ohtake |
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Publication Detail:
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Type: Journal Article Date: 2009-07-03 |
Journal Detail:
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Title: Hemodialysis international. International Symposium on Home Hemodialysis Volume: 13 ISSN: 1542-4758 ISO Abbreviation: Hemodial Int Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-08-25 Completed Date: 2010-02-03 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101093910 Medline TA: Hemodial Int Country: Canada |
Other Details:
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Languages: eng Pagination: 286-92 Citation Subset: IM |
Affiliation:
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Department of Nephrology and Dialysis & Kidney Center, Shonan Kamakura General Hospital, 1202-1 Yamazaki Kamakura, Japan. shuzo@shonankamakura.or.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Atherosclerosis / blood* Blood Platelets / pathology Blood Viscosity Cell Aggregation / physiology Female Flow Cytometry Humans Leukocytes / pathology* Male Middle Aged Platelet Aggregation / physiology Renal Dialysis / adverse effects* Rheology / methods |
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