Document Detail

Increased leukocyte activity as a predictor for flow-limiting coronary lesions in patients with angina pectoris.
MedLine Citation:
PMID:  11583729     Owner:  NLM     Status:  MEDLINE    
Myocardial ischemia initiates an acute inflammatory response, in which polymorphonuclear leukocytes (PMNs) are major participants. We investigated whether increased PMN activity in the peripheral blood is a marker for high-grade coronary artery stenosis in patients with angina pectoris. PMN activity was examined in 45 patients by measuring the luminol-dependent chemiluminescence (CL) response of the peripheral blood upon addition of phorbol myristate acetate (PMA). The CL of patients with angiographic filling delay was 1.6-fold higher than in patients without delay (480+/-54 vs. 302+/-33 counts/PMN, P<0.01). The CL of patients with a filling delay of the left anterior descending artery (LAD) was 1.7-fold higher than in patients without an LAD filling delay (537+/-79 vs. 317+/-27 counts/PMN, P<0.01). With the CL cut-off at 400 counts/PMN, the sensitivity and specificity for detecting an angiographic filling delay of the LAD were 69 and 75%, respectively. These data indicate that PMN activity in the peripheral blood is increased with the presence of a flow-limiting coronary lesion showing an angiographic filling delay. Measuring PMN activity may be a useful approach to assess indications for and timing of angiography and/or adjunctive invasive therapies in patients with angina pectoris.
S Takeshita; H Hashimoto; Y Ono; M Ochiai; N Yokoyama; M Terakura; T Sato; T Isshiki
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Atherosclerosis     Volume:  158     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-03     Completed Date:  2002-01-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  477-81     Citation Subset:  IM    
Department of Medicine, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi, Tokyo 173-8605, Japan.
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MeSH Terms
Angina Pectoris / blood,  complications,  physiopathology*,  radiography
Chemiluminescent Measurements
Coronary Angiography
Coronary Circulation*
Coronary Stenosis / blood,  complications,  physiopathology*,  radiography
Luminol / pharmacology
Middle Aged
Neutrophil Activation*
Sensitivity and Specificity
Tetradecanoylphorbol Acetate / pharmacology
Reg. No./Substance:
16561-29-8/Tetradecanoylphorbol Acetate; 521-31-3/Luminol

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