| Increased leukocyte activity as a predictor for flow-limiting coronary lesions in patients with angina pectoris. | |
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MedLine Citation:
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PMID: 11583729 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Myocardial ischemia initiates an acute inflammatory response, in which polymorphonuclear leukocytes (PMNs) are major participants. We investigated whether increased PMN activity in the peripheral blood is a marker for high-grade coronary artery stenosis in patients with angina pectoris. PMN activity was examined in 45 patients by measuring the luminol-dependent chemiluminescence (CL) response of the peripheral blood upon addition of phorbol myristate acetate (PMA). The CL of patients with angiographic filling delay was 1.6-fold higher than in patients without delay (480+/-54 vs. 302+/-33 counts/PMN, P<0.01). The CL of patients with a filling delay of the left anterior descending artery (LAD) was 1.7-fold higher than in patients without an LAD filling delay (537+/-79 vs. 317+/-27 counts/PMN, P<0.01). With the CL cut-off at 400 counts/PMN, the sensitivity and specificity for detecting an angiographic filling delay of the LAD were 69 and 75%, respectively. These data indicate that PMN activity in the peripheral blood is increased with the presence of a flow-limiting coronary lesion showing an angiographic filling delay. Measuring PMN activity may be a useful approach to assess indications for and timing of angiography and/or adjunctive invasive therapies in patients with angina pectoris. |
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Authors:
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S Takeshita; H Hashimoto; Y Ono; M Ochiai; N Yokoyama; M Terakura; T Sato; T Isshiki |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Atherosclerosis Volume: 158 ISSN: 0021-9150 ISO Abbreviation: Atherosclerosis Publication Date: 2001 Oct |
Date Detail:
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Created Date: 2001-10-03 Completed Date: 2002-01-22 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0242543 Medline TA: Atherosclerosis Country: Ireland |
Other Details:
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Languages: eng Pagination: 477-81 Citation Subset: IM |
Affiliation:
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Department of Medicine, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi, Tokyo 173-8605, Japan. stake@blue.ocn.ne.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angina Pectoris
/
blood,
complications,
physiopathology*,
radiography Chemiluminescent Measurements Coronary Angiography Coronary Circulation* Coronary Stenosis / blood, complications, physiopathology*, radiography Female Humans Luminol / pharmacology Male Middle Aged Neutrophil Activation* Sensitivity and Specificity Tetradecanoylphorbol Acetate / pharmacology |
| Chemical | |
Reg. No./Substance:
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16561-29-8/Tetradecanoylphorbol Acetate; 521-31-3/Luminol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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