| Increased left ventricular mass in pre-liver transplantation cirrhotic patients. | |
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MedLine Citation:
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PMID: 18192806 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Severe liver disease is associated with abnormalities in cardiac geometry and function. We aimed to assess the prevalence of these abnormalities and to determine if they represent an adaptation of the heart to the haemodynamic overload associated with liver dysfunction. METHODS: Seventy cirrhotic patients underwent standard Doppler echocardiography, as a screening evaluation for liver transplantation, and were compared with 70 normal subjects matched for age and sex. The values of echocardiographically measured left ventricular mass (LVM) were compared with those predicted from individual haemodynamic load, sex and height, which represent the compensatory values. LVM was considered inappropriately high when the observed/predicted LVM ratio was >128%. RESULTS: Cirrhotic patients had higher LVM index (40.6 +/- 11.2 vs. 36.3 +/- 7.7 g/m; P = 0.009)), similar values of ejection fraction, but lower intrinsic wall mechanics (P < 0.01) compared to controls. The observed/predicted LVM ratio was also significantly increased (117.7 +/- 30.2 vs. 106.5 +/- 16.8%; P < 0.01) and prevalence of inappropriate LVM was almost three-fold higher in cirrhotic patients (27.7 vs. 10.0%; P < 0.05) than in controls. Cirrhotic patients also presented mild impairment of left ventricular systolic function, documented by lower values of midwall shortening. CONCLUSIONS: Patients with severe liver disease have LVM values exceeding the compensatory needs to sustain haemodynamic overload, associated with subclinical systolic dysfunction. |
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Authors:
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Marina De Marco; Marcello Chinali; Carmela Romano; Margherita Benincasa; Gianpaolo D'Addeo; Luciano D'Agostino; Giovanni de Simone |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of cardiovascular medicine (Hagerstown, Md.) Volume: 9 ISSN: 1558-2027 ISO Abbreviation: J Cardiovasc Med (Hagerstown) Publication Date: 2008 Feb |
Date Detail:
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Created Date: 2008-01-14 Completed Date: 2008-04-10 Revised Date: 2009-05-28 |
Medline Journal Info:
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Nlm Unique ID: 101259752 Medline TA: J Cardiovasc Med (Hagerstown) Country: United States |
Other Details:
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Languages: eng Pagination: 142-6 Citation Subset: IM |
Affiliation:
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Echocardiography Laboratory, Department of Clinical and Experimental Medicine, Federico II University Hospital, Naples, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Echocardiography, Doppler Female Hemodynamics Humans Hypertrophy, Left Ventricular* / physiopathology, ultrasonography Liver Cirrhosis / physiopathology* Liver Transplantation Male Middle Aged Ventricular Dysfunction, Left* / physiopathology |
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