Document Detail


Increased left ventricular emptying at maximal exercise after reduction in afterload.
MedLine Citation:
PMID:  6692510     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Twelve healthy men were studied by M mode echocardiography during exercise to investigate the effect of afterload reduction on left ventricular function at maximal exertion. They performed two maximal exercise bicycle tests 4 hr apart while in the semisupine position and were given 20 mg nifedipine sublingually 30 min before the second test. During the first test end-systolic dimension decreased (p less than .01) and fractional shortening increased from rest to peak exercise (p less than .01), while end-diastolic dimension did not change significantly. At maximal exercise systolic blood pressure was lower after nifedipine than in the preceding control test (202 +/- 10 [mean +/- SD] vs 212 +/- 14 mm Hg; p less than .01), while heart rate was not significantly changed (168 +/- 15 vs 162 +/- 13 beats/min). End-systolic dimension was lower (25.6 +/- 3.3 vs 28.8 +/- 4.2 mm; p less than .01) and fractional shortening higher (50.7 +/- 6.0% vs 45.3 +/- 7.0%; p less than .01) while end-diastolic dimension was unchanged (52.3 +/- 1.9 vs 52.4 +/- 2.6 mm). Our data indicate increased left ventricular emptying at maximal exercise after nifedipine, most probably due to reduction in afterload.
Authors:
K Andersen; H Vik-Mo
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Circulation     Volume:  69     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1984 Mar 
Date Detail:
Created Date:  1984-03-14     Completed Date:  1984-03-14     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  492-6     Citation Subset:  AIM; IM; S    
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MeSH Terms
Descriptor/Qualifier:
Adult
Blood Pressure / drug effects
Cardiac Output / drug effects*
Echocardiography
Exercise Test
Heart Rate / drug effects
Humans
Male
Myocardial Contraction / drug effects*
Nifedipine / pharmacology*
Physical Exertion*
Stroke Volume / drug effects*
Time Factors
Chemical
Reg. No./Substance:
21829-25-4/Nifedipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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