| Increased left ventricular emptying at maximal exercise after reduction in afterload. | |
| | |
MedLine Citation:
|
PMID: 6692510 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Twelve healthy men were studied by M mode echocardiography during exercise to investigate the effect of afterload reduction on left ventricular function at maximal exertion. They performed two maximal exercise bicycle tests 4 hr apart while in the semisupine position and were given 20 mg nifedipine sublingually 30 min before the second test. During the first test end-systolic dimension decreased (p less than .01) and fractional shortening increased from rest to peak exercise (p less than .01), while end-diastolic dimension did not change significantly. At maximal exercise systolic blood pressure was lower after nifedipine than in the preceding control test (202 +/- 10 [mean +/- SD] vs 212 +/- 14 mm Hg; p less than .01), while heart rate was not significantly changed (168 +/- 15 vs 162 +/- 13 beats/min). End-systolic dimension was lower (25.6 +/- 3.3 vs 28.8 +/- 4.2 mm; p less than .01) and fractional shortening higher (50.7 +/- 6.0% vs 45.3 +/- 7.0%; p less than .01) while end-diastolic dimension was unchanged (52.3 +/- 1.9 vs 52.4 +/- 2.6 mm). Our data indicate increased left ventricular emptying at maximal exercise after nifedipine, most probably due to reduction in afterload. |
| | |
Authors:
|
K Andersen; H Vik-Mo |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Circulation Volume: 69 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1984 Mar |
Date Detail:
|
Created Date: 1984-03-14 Completed Date: 1984-03-14 Revised Date: 2008-11-21 |
Medline Journal Info:
|
Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 492-6 Citation Subset: AIM; IM; S |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Blood Pressure / drug effects Cardiac Output / drug effects* Echocardiography Exercise Test Heart Rate / drug effects Humans Male Myocardial Contraction / drug effects* Nifedipine / pharmacology* Physical Exertion* Stroke Volume / drug effects* Time Factors |
| Chemical | |
Reg. No./Substance:
|
21829-25-4/Nifedipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Recording of diastolic slope with catheters during junctional rhythm in humans.
Next Document: Echocardiographic measurement of right ventricular volume.