Document Detail


Increased laminin-1 expression in hydatidiform mole.
MedLine Citation:
PMID:  9464856     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To investigate the aetiology of hydatidiform mole, laminin-1 expression was determined in human villous tissues obtained from normal pregnancies (n = 17) and complete hydatidiform moles (n = 10). Indirect immunofluorescent staining was performed to detect laminin-1, and Northern blot analysis was performed to assess expression of laminin mRNA. Serum concentrations of laminin P-1 were also measured. Immunohistochemical analysis revealed stronger staining of the trophoblastic basement membrane in hydatidiform mole than in normal pregnancy. Northern blot analysis revealed that villous expression of laminin mRNA was significantly increased in hydatidiform mole compared with normal pregnancy (P < 0.05). The serum laminin P-1 concentration was also significantly higher in those patients with hydatidiform mole than in normal pregnancy (P < 0.05). These results suggest that laminin-1 might play an important role in determining the pathophysiology and structure of hydatidiform mole. In addition, measurement of serum laminin P-1 in combination with human chorionic gonadotrophin might be useful in the diagnosis of hydatidiform mole, to evaluate the prognosis, and to detect the presence of metastatic or recurrent disease.
Authors:
M Iwahashi; Y Muragaki; A Ooshima; R Nakano
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Molecular human reproduction     Volume:  3     ISSN:  1360-9947     ISO Abbreviation:  Mol. Hum. Reprod.     Publication Date:  1997 Dec 
Date Detail:
Created Date:  1998-03-10     Completed Date:  1998-03-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9513710     Medline TA:  Mol Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1107-11     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynaecology, Wakayama Medical College, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Blotting, Northern
Female
Goats
Humans
Hydatidiform Mole / metabolism*
Immunohistochemistry
Laminin / biosynthesis*,  blood,  genetics,  immunology
Peptide Fragments / biosynthesis*,  blood,  genetics,  immunology
Pregnancy
RNA, Messenger / analysis
Rabbits
Staining and Labeling
Uterine Neoplasms / metabolism*
Chemical
Reg. No./Substance:
0/Laminin; 0/Peptide Fragments; 0/RNA, Messenger; 0/laminin P1

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