Document Detail

Increased kynurenic acid in the brain after neonatal asphyxia.
MedLine Citation:
PMID:  11521749     Owner:  NLM     Status:  MEDLINE    
In the brain, L-kynurenine is an intermediate for the formation of kynurenic acid, a metabolite with neuroprotective activities, and a substrate for the synthesis of 3-hydroxy-kynurenine, a metabolite with neurotoxic properties. In the present study, alterations of L-kynurenine, 3-hydroxy-kynurenine and kynurenic acid levels were examined in the brain of neonatal (10 minutes old) rats after 5, 10, 15 or 20 minutes of asphyxia, and in the brain of the corresponding caesarean-delivered controls, using sensitive high-performance liquid chromatographic methods. Among kynurenines we found a marked time-dependent increase of kynurenic acid levels, a moderately delayed increase of 3-hydroxy-kynurenine, and a trend for a decrease of L-kynurenine content. Thus, the brain reacted rapidly to the oxygen deficit by increasing kynurenic acid levels by 44% already after 5 minutes of asphyxia, and the most prominent elevation of kynurenic acid (302% of control) was found after 20 minutes of asphyxia--the critical time limit of survival.
H Baran; B Kepplinger; M Herrera-Marschitz; K Stolze; G Lubec; H Nohl
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Life sciences     Volume:  69     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-08-27     Completed Date:  2001-09-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  1249-56     Citation Subset:  IM    
Institute of Pharmacology and Toxicology, Veterinary Medical University Vienna, Austria.
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MeSH Terms
Animals, Newborn / metabolism*
Asphyxia / metabolism*
Brain / metabolism*
Disease Models, Animal
Kynurenic Acid / metabolism*
Kynurenine / analogs & derivatives*,  metabolism
Rats, Sprague-Dawley
Time Factors
Reg. No./Substance:
343-65-7/Kynurenine; 484-78-6/3-hydroxykynurenine; 492-27-3/Kynurenic Acid

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