| Increased isoprostane levels in oleic acid-induced lung injury. | |
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MedLine Citation:
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PMID: 19664592 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study was performed to examine a role of oxidative stress in oleic acid-induced lung injury model. Fifteen anesthetized sheep were ventilated and instrumented with a lung lymph fistula and vascular catheters for blood gas analysis and measurement of isoprostanes (8-epi prostaglandin F2alpha). Following stable baseline measurements, oleic acid (0.08 ml/kg) was administered and observed 4 h. Isoprostane was measured by gas chromatography mass spectrometry with the isotope dilution method. Isoprostane levels in plasma and lung lymph were significantly increased 2 h after oleic acid administration and then decreased at 4 h. The percent increases in isoprostane levels in plasma and lung lymph at 2 h were significantly correlated with deteriorated oxygenation at the same time point, respectively. These findings suggest that oxidative stress is involved in the pathogenesis of the pulmonary fat embolism-induced acute lung injury model in sheep and that the increase relates with the deteriorated oxygenation. |
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Authors:
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Koichi Ono; Tomonobu Koizumi; Kenji Tsushima; Sumiko Yoshikawa; Toshiki Yokoyama; Rikimaru Nakagawa; Toru Obata |
Publication Detail:
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Type: Journal Article Date: 2009-08-05 |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 388 ISSN: 1090-2104 ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-08-31 Completed Date: 2009-09-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
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Languages: eng Pagination: 297-300 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology and Resuscitation, Shinshu University School of Medicine, Matsumoto, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Lung Injury
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blood,
chemically induced,
metabolism* Animals Disease Models, Animal Isoprostanes / analysis, blood, metabolism* Oleic Acid / toxicity* Sheep |
| Chemical | |
Reg. No./Substance:
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0/Isoprostanes; 112-80-1/Oleic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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