| Increased islet blood flow in obese rats: role of the autonomic nervous system. | |
| | |
MedLine Citation:
|
PMID: 1590384 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Hyperinsulinemia, a main feature of both human and animal obesity, has been demonstrated to be due to both an increased sensitivity to nutrient secretagogues and an impairment of the nervous regulation of insulin secretion. Recent studies have shown that pancreatic islet blood flow increases under conditions associated with an enhanced insulin secretion. The aim of this study was to determine whether or not changes in islet blood flow are present in hyperinsulinemic obese rats. Using the nonradioactive microsphere technique, we were able to show a significantly higher islet blood flow in obese rats either of the Zucker strain or Wistar rats after lesion of the ventromedial hypothalamus than in their respective lean controls. Subdiaphragmatic vagotomy had no significant effect on basal islet blood flow of lean rats, whereas it decreased significantly that of obese Zucker rats. Conversely, clonidine, an alpha 2-adrenergic agonist, induced a higher decrease of islet blood flow in obese than in lean Zucker rats. The injection of an intravenous bolus of glucose (375 mg/kg iv) increased significantly more islet blood flow in obese than in lean Zucker rats. It is concluded that obese rats present an increased pancreatic islet blood flow, which may result, at least in part, from exaggerated parasympathetic activity and lower than normal sympathetic activity. This could participate in the hyperinsulinemia observed in these rats. |
| | |
Authors:
|
N Atef; A Ktorza; L Picon; L Pénicaud |
Related Documents
:
|
6972084 - Studies on recovery and variation of pancreatic juice obtained by endoscopic cannulatio... 2033324 - A study of the time course of conversion of edematous to hemorrhagic pancreatitis. 4033194 - Effect of increased systemic venous pressure on thoracic duct and peripheral lymph flow... 1121644 - On the fate of dna synthesizing lymphoid blood cells in hodgkin's disease. 22289724 - Comparative evaluation of nasal blood flow and airflow in the decongestant response to ... 3760044 - Subarachnoid hemorrhage in the rat: cerebral blood flow and glucose metabolism after se... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The American journal of physiology Volume: 262 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1992 May |
Date Detail:
|
Created Date: 1992-06-25 Completed Date: 1992-06-25 Revised Date: 2003-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: E736-40 Citation Subset: IM |
Affiliation:
|
Laboratoire de Physiopathologie de la Nutrition, Centre National de la Recherche Scientifique, Unité de Recherche Associée 307, Université Paris VII, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Autonomic Nervous System / physiopathology* Clonidine / pharmacology Female Glucose / pharmacology Hyperinsulinism / physiopathology Hypothalamus / physiopathology Injections, Intravenous Islets of Langerhans / blood supply* Obesity / physiopathology* Rats Rats, Inbred Strains Rats, Zucker Regional Blood Flow Vagotomy |
| Chemical | |
Reg. No./Substance:
|
4205-90-7/Clonidine; 50-99-7/Glucose |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Sepsis-induced cascade of cytokine mRNA expression: correlation with metabolic changes.
Next Document: Quantification of hormone pulsatility via an approximate entropy algorithm.