| Increased intratumoral expression of prostate secretory protein of 94 amino acids predicts for worse disease recurrence and progression after radical prostatectomy in patients with prostate cancer. | |
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MedLine Citation:
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PMID: 15833515 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: To examine the impact of prostate secretory protein of 94 amino acids (PSP94) expression within the primary tumor on disease recurrence and progression using radical prostatectomy specimens from patients with adenocarcinoma of the prostate. METHODS: PSP94 immunohistochemistry was performed on 59 radical prostatectomy specimens. The degree of PSP94 expression was reported as either present (group 1) or absent (group 2). Clinical data, including survival outcome measures, were correlated with PSP94 expression. RESULTS: The time to disease progression for group 1 was shorter compared with that for group 2 (P = 0.042). Disease-free survival was also less in group 1 than in group 2 (P = 0.033). Multivariate analyses demonstrated that PSP94 expression was an independent prognostic factor for a shorter interval to disease progression (P = 0.046) and disease-free survival (P = 0.049). CONCLUSIONS: PSP94 expression in radical prostatectomy tumor specimens appears to be associated with worsened survival outcomes and may provide additional prognostic information. |
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Authors:
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Andrew R Girvan; Peter Chang; Isaac van Huizen; Madeleine Moussa; Jim W Xuan; Larry Stitt; Joseph L Chin; Yasuto Yamasaki; Jonathan I Izawa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Urology Volume: 65 ISSN: 1527-9995 ISO Abbreviation: Urology Publication Date: 2005 Apr |
Date Detail:
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Created Date: 2005-04-18 Completed Date: 2005-12-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0366151 Medline TA: Urology Country: United States |
Other Details:
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Languages: eng Pagination: 719-23 Citation Subset: IM |
Affiliation:
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Department of Surgery, Division of Urology, Clinical Cancer Research Program, The London Regional Cancer Centre, London, Ontario, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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chemistry,
metabolism*,
surgery* Aged Disease Progression Follow-Up Studies Humans Male Middle Aged Neoplasm Recurrence, Local / chemistry, metabolism* Predictive Value of Tests Prostatectomy* Prostatic Neoplasms / chemistry, metabolism*, surgery* Prostatic Secretory Proteins / analysis, biosynthesis* |
| Chemical | |
Reg. No./Substance:
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0/Prostatic Secretory Proteins; 0/beta-microseminoprotein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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