Document Detail


Increased intraocular pressure during treatment for chronic uveitis.
MedLine Citation:
PMID:  9143886     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: (1) To prospectively evaluate the incidence of increased intraocular pressure (IOP) in patients suffering from chronic uveitis. (2) To identify the main factors responsible for an increase in the IOP among these patients. METHODS: Two hundred and one patients suffering from chronic uveitis were included. Enrolled patients had an initial IOP of 8-18 mmHg. The patients were treated and clinically monitored during a period of 4 years. The IOP was measured at each visit and its changes followed prospectively. All patients were followed up for at least 12 months after enrollment. RESULTS: Twenty-four (12%) of the 201 patients had IOP higher than 24 mmHg at two or more consecutive visits. Of these 24 patients, 19 suffered from bilateral uveitis and 5 had unilateral disease. Four of the 19 patients with bilateral uveitis developed a constant IOP higher than 24 mmHg in both eyes, while in 15 patients an IOP higher than 24 mmHg persisted only in one eye. A close association between the increased IOP and the use of corticosteroids was found in 18 of the 24 cases (75%). This association was ascertained in 16 of these patients by the decrease in IOP levels on discontinuation of the corticosteroid regimen and the renewed increase IOP was due to pupillary block in three cases (12.5%), to iris and angle neovascularization in two (8.3%), and to the inflammatory process per se in one case only (4.2%). CONCLUSIONS: This study demonstrates that a persistent elevation of the IOP in patients suffering from chronic uveitis is, in the majority of cases, associated with the use of corticosteroids.
Authors:
D BenEzra; Y S Wysenbeek; E Cohen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv für klinische und experimentelle Ophthalmologie     Volume:  235     ISSN:  0721-832X     ISO Abbreviation:  Graefes Arch. Clin. Exp. Ophthalmol.     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-07-28     Completed Date:  1997-07-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8205248     Medline TA:  Graefes Arch Clin Exp Ophthalmol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  200-3     Citation Subset:  IM    
Affiliation:
Department of Ophthalmology, Hadassah University Hospital, Jerusalem, Israel.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adrenergic beta-Antagonists / therapeutic use
Adult
Aged
Aged, 80 and over
Chronic Disease
Dexamethasone / administration & dosage,  adverse effects*,  therapeutic use
Dose-Response Relationship, Drug
Drug Therapy, Combination
Female
Fluorometholone / administration & dosage,  adverse effects,  therapeutic use
Follow-Up Studies
Glucocorticoids / administration & dosage,  adverse effects*,  therapeutic use
Humans
Intraocular Pressure / drug effects*
Male
Middle Aged
Ocular Hypertension / chemically induced*,  therapy
Ophthalmic Solutions
Prednisolone / administration & dosage,  adverse effects,  therapeutic use
Prospective Studies
Uveitis / drug therapy*,  etiology
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Glucocorticoids; 0/Ophthalmic Solutions; 426-13-1/Fluorometholone; 50-02-2/Dexamethasone; 50-24-8/Prednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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