| Increased intramuscular nerve branching and inhibition of programmed cell death of chick embryo motoneurons by immunoglobulins from patients with motoneuron disease. | |
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MedLine Citation:
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PMID: 20800908 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Massive programmed cell death (PCD) of developing chick embryo motoneurons (MNs) occurs in a well defined temporal and spatial sequence between embryonic day (E) 6 and E10. We have found that, when administered in ovo, either circulating immunoglobulins G (IgGs) or cerebrospinal fluid from patients with MN disease can rescue a significant number of chick embryo MNs from normally occurring PCD. An increase of branching of intramuscular nerves was also observed that may account for the rescuing effects of pathologic IgGs. Proteomic analysis and further analysis by ELISA indicated that these effects may be mediated by the interaction of circulating human immunoglobulins with proteins of the semaphorin family. |
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Authors:
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Sara Hernández; Laura Texidó; Jordi Calderó; Dolors Ciutat; Lídia Piedrafita; Anna Casanovas; Joan Blasi; Carles Solsona; Mònica Povedano; Ricardo Rojas; Isabel Illa; James Caress; David Prevette; Ronald W Oppenheim; Carol Milligan; Josep E Esquerda |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of neuroimmunology Volume: 229 ISSN: 1872-8421 ISO Abbreviation: J. Neuroimmunol. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-24 Completed Date: 2010-12-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8109498 Medline TA: J Neuroimmunol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 157-68 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier B.V. All rights reserved. |
Affiliation:
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Universitat de Lleida, Facultat de Medicina, Departament de Medicina Experimental, Lleida, Catalonia, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Apoptosis / drug effects* Cell Survival / drug effects Cells, Cultured Cercopithecus aethiops Chick Embryo Dose-Response Relationship, Drug Electrophoresis, Gel, Two-Dimensional / methods Enzyme-Linked Immunosorbent Assay / methods Female Ganglia, Spinal / cytology Growth Cones / drug effects Humans Immunoglobulins / immunology, pharmacology* Male Motor Neuron Disease / blood, immunology* Motor Neurons / cytology, drug effects* Muscle, Skeletal / embryology, innervation* Neuromuscular Junction / drug effects*, physiology Proteomics / methods Semaphorins / metabolism Serum / chemistry, immunology Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods Statistics as Topic Statistics, Nonparametric Transfection / methods Tubulin / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Immunoglobulins; 0/Semaphorins; 0/Tubulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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