| Increased intragastric pressure gradients are involved in the occurrence of acid reflux in gastroesophageal reflux disease. | |
| | |
MedLine Citation:
|
PMID: 19191069 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: Increased pressure gradients across the esophagogastric junction (DeltaEGJp) play a role in gastroesophageal flow during TLESR. The aim of this study was to further explore DeltaEGJp in patients with gastroesophageal reflux disease (GERD) and controls. MATERIAL AND METHODS: Twenty GERD patients were studied along with 20 control subjects. High resolution manometry and pH recording were performed 1 h before and 2 h after a liquid meal (500 ml/300 kcal). DeltaEGJp was calculated at the start of a TLESR and at 180, 60, and 10 s before TLESR. RESULTS: DeltaEGJp at the start of a TLESR and at 180, 60, and 10 s before TLESR was markedly increased in GERD patients compared with that in control subjects (9.9 mmHg and 7.5 mmHg, respectively; p<0.05). Whilst intragastric pressure gradients in GERD patients were increased compared with those in controls (4.6 mmHg and 2.5 mmHg, respectively; p<0.01), intraesophageal pressure gradients were similar in both groups. Furthermore, in controls, first- and second-hour postprandial intragastric pressures were decreased compared with in fasting periods (1.9 +/- 0.4 mmHg and 2.1 +/- 0.4 mmHg versus 3.5 +/- 0.4 mmHg; p<0.05), while this was not observed in GERD patients. CONCLUSIONS: In GERD patients, DeltaEGJp is greater than that in controls both before and during TLESR. This phenomenon is caused by increased intragastric pressure and might contribute to increased rates of acid reflux during TLESR in GERD patients. |
| | |
Authors:
|
Rutger Frankhuisen; Margot A Van Herwaarden; Robert Ch Scheffer; Geoffrey S Hebbard; Hein G Gooszen; Melvin Samsom |
Related Documents
:
|
1248689 - Pneumatic ileal perforation: an unusual complication of colonoscopy. 3812889 - Determinants of stool frequency after ileal pouch-anal anastomosis. 9179479 - Gastroesophageal sphincter: a model. 12171259 - 5-ht4 receptor enhances the propulsive power of the peristaltic reflex in the rat dista... 12646419 - Role of 5-ht1b/d receptors in canine gastric accommodation: effect of sumatriptan and 5... 1611919 - Pancreatic tissue fluid pressure and pain in chronic pancreatitis. 11867459 - Application of pressure perturbation calorimetry to lipid bilayers. 2535309 - Vasodilator properties of atrial natriuretic factor: a comparison with nitroglycerin, n... 15245669 - The comparison of the oxidative stress effects of different gases and intra-abdominal p... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Scandinavian journal of gastroenterology Volume: 44 ISSN: 1502-7708 ISO Abbreviation: Scand. J. Gastroenterol. Publication Date: 2009 |
Date Detail:
|
Created Date: 2009-04-28 Completed Date: 2009-07-27 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0060105 Medline TA: Scand J Gastroenterol Country: Norway |
Other Details:
|
Languages: eng Pagination: 545-50 Citation Subset: IM |
Affiliation:
|
Department of Gastroenterology, University Medical Center Utrecht, Utrecht, The Netherlands. rutgerfrankhuisen@gmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Analysis of Variance Case-Control Studies Esophageal Sphincter, Lower / physiopathology* Esophageal pH Monitoring Esophagogastric Junction / physiopathology* Female Gastric Acid / metabolism* Gastroesophageal Reflux / diagnosis* Humans Male Manometry / methods* Middle Aged Muscle Relaxation / physiology* Pressure Probability Reference Values Sensitivity and Specificity |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Plasma predilution with addition of depleted plasma in a prothrombin time reagent improves the agree...
Next Document: The value and meaning of an instrumental occupation performed in a clinical setting.