| Increased intracellular growth of Mycobacterium avium in HIV-1 exposed monocyte-derived dendritic cells. | |
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MedLine Citation:
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PMID: 21078405 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Dendritic cells (DC) are the most potent antigen-presenting cells, and form a link between the innate and adaptive immune system. They sample the periphery of the body for antigens and present them to T cells to elicit a proper immune response. It has been shown that dendritic cells phagocytose mycobacteria, but there have been conflicting reports as to whether the bacteria are capable of intracellular replication in DCs. Mycobacterium avium is a facultative intracellular bacterium, part of the Mycobacterium avium complex (MAC) of mycobacteria and are commonly seen as opportunistic pathogens in patients infected by Human immunodeficiency virus type 1 (HIV-1). To clarify the issue of whether DCs are capable of controlling the intracellular growth of M. avium and whether this control is lost upon HIV-1 exposure, we investigated the intracellular replication of M. avium in monocyte-derived dendritic cells and compared it to bacterial growth in dendritic cultures exposed to HIV-1 for 24 h. Our results show that exposure of DCs to HIV-1 promotes or facilitates the intracellular growth of M. avium. |
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Authors:
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Tore Salte; Sharad Pathak; Tore Wentzel-Larsen; Birgitta Asjö |
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Publication Detail:
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Type: Journal Article Date: 2010-11-13 |
Journal Detail:
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Title: Microbes and infection / Institut Pasteur Volume: 13 ISSN: 1769-714X ISO Abbreviation: Microbes Infect. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-01-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883508 Medline TA: Microbes Infect Country: France |
Other Details:
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Languages: eng Pagination: 276-83 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Institut Pasteur. Published by Elsevier SAS. All rights reserved. |
Affiliation:
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Section for Microbiology and Immunology, The Gade Institute, University of Bergen, Laboratory Building, 5th floor, Haukeland University Hospital, N-5021 Bergen, Norway. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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