| Increased intima-media thickness of the common carotid artery in primary aldosteronism in comparison with essential hypertension. | |
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MedLine Citation:
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PMID: 17563568 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Aldosterone contributes to the accumulation of collagen fibers and extracellular matrix in arterial wall. The aim of this study was to compare intima-media thickness (IMT) of the common carotid artery and carotid bifurcation in patients with primary aldosteronism, essential hypertension and healthy controls. METHODS: Carotid ultrasound studies were carried out in 33 patients aged 42-72 years with primary aldosteronism, 52 patients with essential hypertension and in 33 normotensive controls. RESULTS: The patients with primary aldosteronism had significantly higher IMT of the common carotid artery than patients with essential hypertension and controls (0.987 +/- 0.152 mm; 0.892 +/- 0.154 mm versus 0.812 +/- 0.124 mm; P < 0.001; P < 0.05). There was also significantly higher IMT of the common carotid in patients with essential hypertension compared to control group (0.892 +/- 0.154 mm versus 0.812 +/- 0.124 mm; P < 0.01). The differences between both hypertensive groups remained statistically significant after adjustment for age and 24-h systolic blood pressure (P = 0.001). The differences of the IMT in the carotid bifurcation were statistically significant only between patients with primary aldosteronism and controls (1.157 +/- 0.243 mm versus 0.994 +/- 0.199 mm; P <0.05). CONCLUSION: Patients with primary aldosteronism have increased common carotid IMT compared to the patients with essential hypertension. This finding could be caused by the deleterious effects of aldosterone excess on the fibrosis and thickening of the arterial wall, mainly in the straight segments of vessels. |
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Authors:
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Robert Holaj; Tomás Zelinka; Dan Wichterle; Ondrej Petrák; Branislav Strauch; Jirí Widimský |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of hypertension Volume: 25 ISSN: 0263-6352 ISO Abbreviation: J. Hypertens. Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-06-12 Completed Date: 2007-08-02 Revised Date: 2008-10-23 |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 1451-7 Citation Subset: IM |
Affiliation:
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First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. rholaj@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Carotid Artery, Common / pathology*, ultrasonography Echocardiography, Doppler Female Humans Hyperaldosteronism / pathology*, ultrasonography Hypertension / pathology*, ultrasonography Male Middle Aged Tunica Intima / pathology*, ultrasonography Tunica Media / pathology*, ultrasonography |
| Comments/Corrections | |
Comment In:
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J Hypertens. 2008 Jul;26(7):1499-500; author reply 1500-1
[PMID:
18551030
]
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Erratum In:
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J Hypertens. 2007 Aug;25(8):1749 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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