Document Detail


Increased intima media thickness and atherosclerotic plaques in the carotid artery as risk factors for silent brain infarcts.
MedLine Citation:
PMID:  17689386     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The presence of silent cerebral infarcts (SCIs), defined as lesions > or = 3 mm in diameter on magnetic resonance imaging (MRI), is considered a predictor of symptomatic cerebrovascular disorders (CVDs). Similarly, SCI-like lesions < 3 mm in diameter, lesions which often occur in the deep white matter and basal ganglia, also may be a risk factor for CVD. This study evaluated the relationships between SCI and SCI-like brain lesions, as defined by MRI, and 2 findings on extracranial carotid ultrasonography: intima-media thickness (IMT) and atherosclerotic plaque. We studied data obtained by carotid ultrasonography and cerebral MRI in 448 consecutive subjects without a history of stroke who had undergone comprehensive brain screening (mean age, 51.1 years). The subjects were classified into 4 groups according to the presence of increased (> or = 1 mm) IMT (I) and plaque (P). A total of 110 subjects demonstrated increased IMT (24.6%), and 54 subjects had increased plaque (12.1%). SCI-like lesions were found in 38 subjects (8.5%); single SCI, in 24 (5.4%); and multiple SCIs, in 51 (11.4%). Frequencies of SCI-like lesion(s), single SCI, and multiple SCIs were 6.1%, 12.2%, and 8.7%, respectively, in the I(-)P(-) group; 14.6%, 22.0%, and 13.4% in the I(+)P(-) group; 7.7%, 30.8%, and 26.9% in the I(-)P(+) group; and 17.9%, 39.3%, and 21.4% in the I(+)P(+) group. Multivariate analysis found that the presence of carotid plaques was significantly associated with (1) SCI-like lesion(s) and SCI (odds ratio [OR] = 2.20; 95% confidence interval [CI] = 1.17-4.34), (2) single and multiple SCI (OR = 2.33; 95% CI = 1.16-4.67), and (3) multiple SCIs (OR = 2.31; 95% CI = 1.06-5.03). However, the presence of increased carotid IMT was not significantly associated with any of these 3 categories. Coexistence of increased IMT and plaque was more strongly correlated with SCI than with either lesion alone.
Authors:
Kazuo Inoue; Masatoshi Matsumoto; Teiji Shono; Satoshi Toyokawa; Akihito Moriki
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association     Volume:  16     ISSN:  1532-8511     ISO Abbreviation:  J Stroke Cerebrovasc Dis     Publication Date:    2007 Jan-Feb
Date Detail:
Created Date:  2007-08-10     Completed Date:  2007-09-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111633     Medline TA:  J Stroke Cerebrovasc Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  14-20     Citation Subset:  IM    
Affiliation:
Department of Public Health, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Brain / pathology
Carotid Stenosis / complications*,  pathology,  ultrasonography
Cerebral Infarction / diagnosis,  epidemiology*,  etiology,  pathology
Comorbidity
Diabetes Mellitus / epidemiology
Female
Humans
Hyperlipidemias / epidemiology
Hypertension / epidemiology
Magnetic Resonance Imaging
Male
Mass Screening
Middle Aged
Obesity / epidemiology
Questionnaires
Risk Factors
Single-Blind Method
Tunica Intima / pathology*,  ultrasonography
Tunica Media / pathology*,  ultrasonography

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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