| Increased intestinal permeability to differently sized polyethylene glycols in uremic rats: effects of low- and high-protein diets. | |
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MedLine Citation:
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PMID: 2077413 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intestinal mucosa forms an important barrier towards harmful agents in the intestinal lumen, besides being the site for absorption of nutrients. Little is known about the intestinal permeability properties in chronic uremia. The permeability toward differently sized polyethylene glycols (PEGs; range 326-1,162 Da) was studied in uremic groups compared to the control groups. The urinary recovery was also recovery of PEGs was increased in the uremic groups compared to the control groups. The urinary recovery was also increased in the groups on the high-protein diet compared to the corresponding group on the low-protein diet. This study suggests an increased permeability of PEG molecules in the range of 546-1,162 Da in uremic rats and a decreased intestinal permeability after a low-protein diet in both a uremic and nonuremic state. Thus, in chronic renal failure the intestinal barrier is impaired but returns towards normal with low-protein diets. |
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Authors:
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M Magnusson; K E Magnusson; T Sundqvist; T Denneberg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Nephron Volume: 56 ISSN: 0028-2766 ISO Abbreviation: Nephron Publication Date: 1990 |
Date Detail:
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Created Date: 1991-04-22 Completed Date: 1991-04-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0331777 Medline TA: Nephron Country: SWITZERLAND |
Other Details:
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Languages: eng Pagination: 306-11 Citation Subset: IM |
Affiliation:
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Department of Nephrology, University of Linköping, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dietary Proteins / pharmacology Dose-Response Relationship, Drug Intestine, Small / metabolism* Kidney / physiopathology Male Permeability / drug effects Polyethylene Glycols / metabolism, pharmacokinetics* Proteinuria / metabolism Rats Rats, Inbred Strains Uremia / metabolism* |
| Chemical | |
Reg. No./Substance:
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0/Dietary Proteins; 0/Polyethylene Glycols |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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