Document Detail


Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease.
MedLine Citation:
PMID:  19291785     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSIONS: Our results provide the first evidence that NAFLD in humans is associated with increased gut permeability and that this abnormality is related to the increased prevalence of SIBO in these patients. The increased permeability appears to be caused by disruption of intercellular tight junctions in the intestine, and it may play an important role in the pathogenesis of hepatic fat deposition.
Authors:
Luca Miele; Venanzio Valenza; Giuseppe La Torre; Massimo Montalto; Giovanni Cammarota; Riccardo Ricci; Roberta Mascianà; Alessandra Forgione; Maria L Gabrieli; Germano Perotti; Fabio M Vecchio; Gianlodovico Rapaccini; Giovanni Gasbarrini; Chris P Day; Antonio Grieco
Related Documents :
19375605 - Electrophysiologic, morphologic, and serologic features of chronic unexplained nausea a...
21559265 - Achievement of right ventricular pacing by use of a long guiding catheter in a hemodial...
15112355 - Epidemiology and outcome of crohn's disease in a teaching hospital in riyadh.
10636065 - Gastrointestinal motility in patients with irritable bowel syndrome studied by using ra...
15378185 - Evaluation of dose-volume histograms after prostate seed implantation. 4-year experience.
24372655 - Evaluation of atrial electromechanical delay and its relationship to inflammation and o...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  49     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-03     Completed Date:  2009-07-01     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1877-87     Citation Subset:  IM    
Affiliation:
Institute of Internal Medicine, Catholic University of Rome, Rome, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Fatty Liver / metabolism*
Female
Humans
Intestine, Small / metabolism*,  microbiology,  ultrastructure*
Male
Middle Aged
Permeability
Tight Junctions*
Comments/Corrections
Comment In:
Hepatology. 2009 Jun;49(6):1790-2   [PMID:  19475679 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  SAFE biopsy: a validated method for large-scale staging of liver fibrosis in chronic hepatitis C.
Next Document:  Golgi phosphoprotein 2 (GOLPH2) expression in liver tumors and its value as a serum marker in hepato...