Document Detail

Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease.
MedLine Citation:
PMID:  19291785     Owner:  NLM     Status:  MEDLINE    
CONCLUSIONS: Our results provide the first evidence that NAFLD in humans is associated with increased gut permeability and that this abnormality is related to the increased prevalence of SIBO in these patients. The increased permeability appears to be caused by disruption of intercellular tight junctions in the intestine, and it may play an important role in the pathogenesis of hepatic fat deposition.
Luca Miele; Venanzio Valenza; Giuseppe La Torre; Massimo Montalto; Giovanni Cammarota; Riccardo Ricci; Roberta Mascianà; Alessandra Forgione; Maria L Gabrieli; Germano Perotti; Fabio M Vecchio; Gianlodovico Rapaccini; Giovanni Gasbarrini; Chris P Day; Antonio Grieco
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  49     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-03     Completed Date:  2009-07-01     Revised Date:  2013-05-20    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1877-87     Citation Subset:  IM    
Institute of Internal Medicine, Catholic University of Rome, Rome, Italy.
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MeSH Terms
Fatty Liver / metabolism*
Intestine, Small / metabolism*,  microbiology,  ultrastructure*
Middle Aged
Tight Junctions*
Comment In:
Hepatology. 2009 Jun;49(6):1790-2   [PMID:  19475679 ]

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