Document Detail

Increased intestinal permeability in pathogenesis and progress of nonalcoholic steatohepatitis in rats.
MedLine Citation:
PMID:  17461479     Owner:  NLM     Status:  MEDLINE    
AIM: To investigate whether increased intestinal permeability contributes to the pathogenesis and progress of nonalcoholic steatohepatitis by observing its dynamic change in rat models.
METHODS: Rat models of nonalcoholic steatohepatitis were established by giving a fat-rich diet. The rats were sacrificed at wk 8, 12 and 16 during the study. Rats fed with normal diet were taken as control. Plasma D-lactate, plasma diamine oxidase, serum lipids and liver transaminases were measured in blood of the femoral artery. Hepatic steatosis and inflammation were assessed by haematoxylin-eosin staining.
RESULTS: A rat model of nonalcoholic steatohepatitis was established successfully. Plasma D-lactate level in model group at wk 8, 12 and 16 and diamine oxidase level in model group at wk 12, 16 increased significantly compared with those in control group. There were notable differences of D-lactate and diamine oxidase level in model group between wk 8 and 12 as well as between wk 12 and 16. Serum lipids, liver transaminases and liver injury also increased with disease development.
CONCLUSION: Increased intestinal permeability caused by intestinal bacterial overgrowth and endotoxin-induced intestinal destruction exists in rats with nonalcoholic steatohepatitis, which may partially explain the pathogenesis and progress of this disease.
Xi Jin; Chao-Hui Yu; Guo-Cai Lv; You-Ming Li
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  13     ISSN:  1007-9327     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2007 Mar 
Date Detail:
Created Date:  2007-04-27     Completed Date:  2007-08-09     Revised Date:  2014-09-07    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  1732-6     Citation Subset:  IM    
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MeSH Terms
Amine Oxidase (Copper-Containing) / blood
Disease Models, Animal
Disease Progression
Fatty Liver / etiology*,  physiopathology*
Intestinal Absorption / physiology*
Intestinal Mucosa / pathology,  physiopathology*
Lipids / blood
Liver / enzymology
Rats, Sprague-Dawley
Transaminases / metabolism
Reg. No./Substance:
0/Lipids; EC Oxidase (Copper-Containing); EC 2.6.1.-/Transaminases

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