Document Detail

Increased intestinal permeability in active pulmonary sarcoidosis.
MedLine Citation:
PMID:  1596016     Owner:  NLM     Status:  MEDLINE    
Altered permeability of the gut is a well-described feature in Crohn's disease. Because of pathologic similarities between Crohn's disease and sarcoidosis, we initiated this study to evaluate the permeability of the gut mucosal lining in patients with pulmonary sarcoidosis. A group of 18 patients with biopsy-proven pulmonary sarcoidosis (active n = 8, inactive n = 10) were included in the study. Control groups included 22 patients with Crohn's disease (active n = 12, inactive n = 10), nine untreated patients with recent pulmonary tuberculosis, six patients with coal worker's pneumoconiosis (CWP), eight patients with idiopathic pulmonary fibrosis (IPF), and 16 healthy subjects. All were nonsmokers. The 24-h urinary excretion of 100 microCi 51Cr-ethylenediaminetetraacetic acid (51Cr-EDTA) was used to test the intestinal permeability (IP). As previously demonstrated, patients with active Crohn's disease demonstrated a dramatic increase in IP (7.7 +/- 1.4%) that was clearly reduced in inactive CD (2.34 +/- 0.54%). Patients with active pulmonary sarcoidosis exhibited a marked increased IP to 51Cr-EDTA (4 +/- 0.54%), which was not found in patients with inactive sarcoidosis (1.6 +/- 0.17%). IP was normal in patients with pulmonary tuberculosis (1.03 +/- 0.25%), CWP (2.1 +/- 0.54%), and IPF (1.9 +/- 0.33%) and did not differ from the control group (1.76 +/- 0.23%). In addition, in 6 patients with active pulmonary sarcoidosis, the concentrations of albumin and hyaluronan were measured in jejunal perfusion fluid and compared with those obtained from 10 patients with active Crohn's disease and 16 control subjects.(ABSTRACT TRUNCATED AT 250 WORDS)
B Wallaert; J F Colombel; A Adenis; X Marchandise; R Hallgren; A Janin; A B Tonnel
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American review of respiratory disease     Volume:  145     ISSN:  0003-0805     ISO Abbreviation:  Am. Rev. Respir. Dis.     Publication Date:  1992 Jun 
Date Detail:
Created Date:  1992-07-02     Completed Date:  1992-07-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370523     Medline TA:  Am Rev Respir Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1440-5     Citation Subset:  AIM; IM    
Service de Pneumologie et Immunoallergologie, Hôpital A. Calmette, Lille, France.
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MeSH Terms
Albumins / analysis
Chromium Radioisotopes / diagnostic use
Crohn Disease / metabolism
Edetic Acid / diagnostic use
Hyaluronic Acid / analysis
Intestinal Absorption / physiology*
Intestinal Mucosa / metabolism,  pathology
Jejunum / metabolism
Lung Diseases / metabolism*
Pneumoconiosis / metabolism
Pulmonary Fibrosis / metabolism
Sarcoidosis / metabolism*
Tuberculosis, Pulmonary / metabolism
Reg. No./Substance:
0/Albumins; 0/Chromium Radioisotopes; 60-00-4/Edetic Acid; 9004-61-9/Hyaluronic Acid

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