| Increased intestinal contents viscosity reduces cholesterol absorption efficiency in hamsters fed hydroxypropyl methylcellulose. | |
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MedLine Citation:
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PMID: 8618144 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study was conducted to test the hypothesis that increased intestinal contents viscosity lowers plasma cholesterol concentrations by decreasing cholesterol absorption. Male Golden Syrian hamsters were fed for 4 wk diets containing 0.12% cholesterol, and either 4% cellulose or four different viscosity grades of hydroxypropyl methylcellulose (HPMC). Dietary HPMC confers viscosity in the small intestine but is resistant to fermentation. Cholesterol absorption efficiency was measured using the dual isotope ratio method, and plasma and liver cholesterol concentrations were determined enzymatically. Ex vivo viscosity of intestinal contents supernatants was measured using a Wells-Brookfield cone/plate viscometer, and the means of treatment groups ranged from 6 to 6532 mPa.s. Relative to dietary cellulose, all viscosity grades of HPMC resulted in significantly lower cholesterol absorption efficiency, lower plasma cholesterol concentration, and lower liver cholesteryl ester content. The logarithm of intestinal contents ex vivo viscosity was inversely correlated with dietary cholesterol absorption (r2 = 0.84, P = 0.028). Furthermore, dietary cholesterol absorption was positively correlated with plasma cholesterol concentration (r2 = 0.89, P = 0.017) and liver cholesteryl ester content (r2 = 0.96, P = 0.0031). Thus, the data suggest an independent role of intestinal contents viscosity in lowering plasma cholesterol concentration and liver cholesteryl ester content by reducing cholesterol absorption efficiency. |
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Authors:
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T P Carr; D D Gallaher; C H Yang; C A Hassel |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of nutrition Volume: 126 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 1996 May |
Date Detail:
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Created Date: 1996-06-11 Completed Date: 1996-06-11 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1463-9 Citation Subset: IM |
Affiliation:
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Department of Food Science and Nutrition, University of Minnesota, St. Paul, 55108, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticholesteremic Agents / administration & dosage, pharmacology* Cholesterol / analysis, blood Cholesterol, Dietary / metabolism, pharmacokinetics* Cricetinae Diet Intestinal Absorption / physiology* Intestine, Small / metabolism, physiology* Liver / anatomy & histology, chemistry, metabolism Male Mesocricetus Methylcellulose / administration & dosage, analogs & derivatives*, pharmacology Organ Size Random Allocation Viscosity |
| Chemical | |
Reg. No./Substance:
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0/Anticholesteremic Agents; 0/Cholesterol, Dietary; 57-88-5/Cholesterol; 8063-82-9/hypromellose; 9004-67-5/Methylcellulose |
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