Document Detail

Increased interleukin-4-positive lymphocytes in patients with Hashimoto's thyroiditis and concurrent non-endocrine autoimmune disorders.
MedLine Citation:
PMID:  21623768     Owner:  NLM     Status:  MEDLINE    
A prevalent T helper type 1 (Th1) subset of lymphocytes has been described in Hashimoto's thyroiditis (HT), but whether a similar polarization may characterize HT when associated with non-endocrine autoimmune disorders (NEAD) is not known. The aim of the present study was to analyse the intracellular Th1 and Th2 distinctive cytokines in patients with isolated HT or associated with non-endocrine autoimmune disorders. Intracellular cytokine expression was assessed in peripheral blood lymphocytes (PBL) of 68 out-patients (females = 55; males = 13; median age = 6 years) with HT : 33 had isolated HT and 35 had a concurrent NEAD. The percentage of interferon (IFN)-γ and interleukin (IL)-2 Th1- and IL-4 Th2-positive cells was measured by flow cytometric analysis. We found an increased percentage of IL-2-positive cells in all patients, without differences between patients with isolated HT or associated with NEAD. IFN-γ(+) cells were also increased in both groups, but the median percentage of those with isolated HT was lower than in patients with HT+NEAD (19·0 versus 29·9%; P = 0·0082). An increased number of IL-4-positive cells was observed in three of 33 (9·1%) patients with isolated HT and in 25 of 35 patients with NEAD [71%; P < 0·0001; relative risk (RR) = 3·18]. The median values of IL-4(+) cells (HT = 5·0% versus HT + NEAD = 16·8%) confirmed this large difference (P < 0·0001). A clear-cut increase of IL-4(+) lymphocytes characterizes patients with autoimmune thyroiditis who have associated non-endocrine autoimmune disorders. These findings may represent an initial tool to detect patients with autoimmune thyroiditis in which additional non-endocrine autoimmune disorders may be awaited.
M G Santaguida; S Nardo; S C Del Duca; E Lococo; C Virili; L Gargano; L Lenti; M Centanni
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-05-30
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  165     ISSN:  1365-2249     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-05     Completed Date:  2011-09-07     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  148-54     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. Clinical and Experimental Immunology © 2011 British Society for Immunology.
Endocrinology Unit, Department of Science and Medico-Surgical Biotechnologies, Sapienza University of Rome, Rome, Italy.
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MeSH Terms
Autoimmune Diseases / complications*,  diagnosis*
Cytokines / blood
Diagnosis, Differential
Flow Cytometry
Hashimoto Disease / complications,  diagnosis*,  immunology*
Interferon-gamma / biosynthesis
Interleukin-2 / analysis
Interleukin-4 / analysis*
Lymphocyte Count
Middle Aged
Polyendocrinopathies, Autoimmune / complications,  diagnosis
Th1 Cells / immunology
Th2 Cells / immunology*
Reg. No./Substance:
0/Cytokines; 0/Interleukin-2; 207137-56-2/Interleukin-4; 82115-62-6/Interferon-gamma

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