| Increased interleukin-18 content and angiogenic activity of sera from diabetic (Type 2) patients with background retinopathy. | |
| | |
MedLine Citation:
|
PMID: 16260350 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Hyperglycaemia increases inflammatory cytokine concentration in the blood. Elevated levels of interleukin-18 (IL-18), a cytokine belonging to the interleukin-1 (IL-1) family, were recently reported in patients with Type 2 diabetes mellitus (DM2) and nephropathy. The aim of the present work was an examination of IL-18 concentration in the sera of elderly DM2 patients with nonproliferative retinopathy and age-matched control people and an estimation whether this cytokine plays pro- or anti-angiogenic role in in vivo angiogenic activity of their sera in mice cutaneous angiogenesis test. Recombinant human IL-18 injected intradermally to murine skin induced significant neovascular reaction. DM2 patients sera contained higher concentration of IL-18 and induced stronger neovascular reaction in mice skin than did the sera of corresponding control people. Sera from both groups of people after neutralization with antihuman IL-18 antibodies lost substantial part of their angiogenic activity. |
| | |
Authors:
|
Piotr Skopiński; Ewa Rogala; Barbara Duda-Król; Anna Lipińska; Ewa Sommer; Joanna Chorostowska-Wynimko; Jerzy Szaflik; Iwona Partyka; Ewa Skopińska-Rózewska |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of diabetes and its complications Volume: 19 ISSN: 1056-8727 ISO Abbreviation: J. Diabetes Complicat. Publication Date: 2005 Nov-Dec |
Date Detail:
|
Created Date: 2005-11-01 Completed Date: 2006-02-03 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 9204583 Medline TA: J Diabetes Complications Country: United States |
Other Details:
|
Languages: eng Pagination: 335-8 Citation Subset: IM |
Affiliation:
|
Department of Ophthalmology, 2nd Faculty of Medicine, Warsaw Medical University, Poland. pskopin@ib.amwaw.edu.pl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Animals Case-Control Studies Diabetes Mellitus, Type 2 / blood* Diabetic Retinopathy / blood* Female Hemoglobin A, Glycosylated / metabolism Humans Interleukin-18 / blood* Mice Mice, Inbred BALB C Middle Aged Retinal Neovascularization / blood* Skin / blood supply |
| Chemical | |
Reg. No./Substance:
|
0/Hemoglobin A, Glycosylated; 0/Interleukin-18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A copper chelating agent suppresses carbonyl stress in diabetic rat lenses.
Next Document: Early treadmill exercise decreases intrastriatal hemorrhage-induced neuronal cell death and increase...