Document Detail


Increased intake of oily fish in pregnancy: effects on neonatal immune responses and on clinical outcomes in infants at 6 mo.
MedLine Citation:
PMID:  22218160     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Long-chain n-3 PUFAs found in oily fish may have a role in lowering the risk of allergic disease.
OBJECTIVE: The objective was to assess whether an increased intake of oily fish in pregnancy modifies neonatal immune responses and early markers of atopy.
DESIGN: Women (n = 123) were randomly assigned to continue their habitual diet, which was low in oily fish, or to consume 2 portions of salmon per week (providing 3.45 g EPA plus DHA) from 20 wk gestation until delivery. In umbilical cord blood samples (n = 101), we measured n-3 fatty acids, IgE concentrations, and immunologic responses. Infants were clinically evaluated at age 6 mo (n = 86).
RESULTS: Cord blood mononuclear cell (CBMC) production of interleukin (IL)-2, IL-4, IL-5, IL-10, and tumor necrosis factor-α in response to phytohemagglutinin (PHA) and of IL-2 in response to Dermatophagoides pteronyssinus allergen 1 (Derp1) was lower in the salmon group (all P ≤ 0.03). In the subgroup of CBMCs in which an allergic phenotype was confirmed in the mother or father, IL-10 production in response to Toll-like receptor 2, 3, and 4 agonists, ovalbumin, salmon parvalbumin, or Derp1 and prostaglandin E(2) production in response to lipopolysaccharide or PHA was lower in the salmon group (all P ≤ 0.045). Total IgE at birth and total IgE, incidence and severity of atopic dermatitis, and skin-prick-test positivity at 6 mo of age were not different between the 2 groups.
CONCLUSION: Oily fish intervention in pregnancy modifies neonatal immune responses but may not affect markers of infant atopy assessed at 6 mo of age. This trial is registered at clinicaltrials.gov as NCT00801502.
Authors:
Paul S Noakes; Maria Vlachava; Lefkothea-Stella Kremmyda; Norma D Diaper; Elizabeth A Miles; Mich Erlewyn-Lajeunesse; Anthony P Williams; Keith M Godfrey; Philip C Calder
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2012-01-04
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  95     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2012 Feb 
Date Detail:
Created Date:  2012-01-23     Completed Date:  2012-03-06     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  395-404     Citation Subset:  AIM; IM    
Data Bank Information
Bank Name/Acc. No.:
ClinicalTrials.gov/NCT00801502
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MeSH Terms
Descriptor/Qualifier:
Adult
Allergens / pharmacology*
Animals
Causality
Dermatitis, Atopic / epidemiology
Diet*
Dietary Fats / administration & dosage*
Dinoprostone / biosynthesis
Fatty Acids, Omega-3 / pharmacology*
Female
Fetal Blood / metabolism
Fish Oils / pharmacology*
Humans
Hypersensitivity / blood*
Immunoglobulin E / blood
Incidence
Infant
Interleukins / blood
Leukocytes, Mononuclear / drug effects*,  immunology,  metabolism
Male
Phenotype
Pregnancy
Salmon
Seafood
Tumor Necrosis Factor-alpha / blood
Grant Support
ID/Acronym/Agency:
MC_UP_A620_1017//Medical Research Council
Chemical
Reg. No./Substance:
0/Allergens; 0/Dietary Fats; 0/Fatty Acids, Omega-3; 0/Fish Oils; 0/Interleukins; 0/Tumor Necrosis Factor-alpha; 37341-29-0/Immunoglobulin E; K7Q1JQR04M/Dinoprostone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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