| Increased intake of ethanol and dietary fat in galanin overexpressing mice. | |
| | |
MedLine Citation:
|
PMID: 20004335 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Evidence suggests that the orexigenic peptide, galanin (GAL), in the hypothalamic paraventricular nucleus (PVN) has a role in stimulating the consumption of ethanol, in addition to a high-fat diet. This possibility was further examined in mutant mice that overexpress the GAL gene. Two sets of GAL-overexpressors (GALOE) compared with wild-type (WT) controls, maintained on laboratory chow and water, were trained to voluntarily drink increasing concentrations of ethanol, from 3 to 15%. In the GALOE versus WT mice, the results revealed the following: (1) a 35-40% increase in ethanol intake and ethanol preference, which was evident only at the highest (15%) ethanol concentration, in male but not female mice, and was seen with comparisons to littermate and nonlittermate WT controls, (2) a significantly larger, 60-75% increase in ethanol intake and ethanol preference after a day of food deprivation, again only in male GALOE mice, (3) no change in consumption of sucrose or quinine solutions in preference tests, and (4) a 55% increase in consumption of a fat-rich diet during a 2-h test period, in both male and female GALOE mice. These results obtained with overexpression of the GAL gene provide strong support for a physiological role of this peptide in stimulating the consumption of ethanol and a fat-rich diet. They reveal gender differences in the behavioral phenotype, which may reflect GAL's functional relationship to reproductive hormones in the stimulation of consummatory behavior. |
| | |
Authors:
|
Olga Karatayev; Jessica Baylan; Sarah F Leibowitz |
Related Documents
:
|
11911925 - Model predictive controller for biodegradable polyhydroxyalkanoate production in fed-ba... 15278515 - Serum fluoride concentration after sevoflurane anesthesia in ethanol treated rats: spec... 4085905 - Lack of fetal growth retardation in rats consuming alcohol prior to conception but not ... 8123195 - Alcohol and calories: a matter of balance. 11911925 - Model predictive controller for biodegradable polyhydroxyalkanoate production in fed-ba... 1168685 - Characterization of two steroidal ketones and two isoprenoid alcohols in dairy products. |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: Alcohol (Fayetteville, N.Y.) Volume: 43 ISSN: 1873-6823 ISO Abbreviation: Alcohol Publication Date: 2009 Dec |
Date Detail:
|
Created Date: 2009-12-16 Completed Date: 2010-01-27 Revised Date: 2011-09-26 |
Medline Journal Info:
|
Nlm Unique ID: 8502311 Medline TA: Alcohol Country: United States |
Other Details:
|
Languages: eng Pagination: 571-80 Citation Subset: IM |
Affiliation:
|
Laboratory of Behavioral Neurobiology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Alcohol Drinking Animals Body Weight Choice Behavior Dietary Fats / administration & dosage* Eating Female Food Deprivation Galanin / physiology* Male Mice Mice, Inbred C57BL Sex Characteristics Taste |
| Grant Support | |
ID/Acronym/Agency:
|
AA 12881/AA/NIAAA NIH HHS; DA 21518/DA/NIDA NIH HHS; R01 DA021518-16A1/DA/NIDA NIH HHS; R01 DA021518-17/DA/NIDA NIH HHS; R01 DA021518-18/DA/NIDA NIH HHS; R01 DA021518-19/DA/NIDA NIH HHS; R01 MH043422-10/MH/NIMH NIH HHS; R01 MH043422-10S1/MH/NIMH NIH HHS; R01 MH043422-11A3/MH/NIMH NIH HHS; R01 MH043422-12/MH/NIMH NIH HHS; R01 MH043422-13/MH/NIMH NIH HHS; R01 MH043422-14/MH/NIMH NIH HHS; R01 MH043422-15/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Dietary Fats; 88813-36-9/Galanin |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Side effects of proliferation signal inhibitors and their management
Next Document: Nicotinic receptor ligands reduce ethanol intake by high alcohol-drinking HAD-2 rats.