Document Detail

Increased insulin-stimulated glucose uptake by exercised human muscles one day after prolonged physical exercise.
MedLine Citation:
PMID:  1907557     Owner:  NLM     Status:  MEDLINE    
We evaluated whether the increased peripheral insulin sensitivity often reported after physical exercise is generalized or limited to the active musculature. Substrate exchange in leg (previously active) and forearm (previously inactive) were measured by catheterization technique basally and during a hyperinsulinaemic euglycaemic clamp (2 mU insulin kg-1 BW min-1) in nine healthy men before and 1 day after 3-h exercise (50% VO2max). One day after exercise basal glucose uptake was unchanged in the leg, while it was decreased in the forearm (-61%, P less than 0.01) compared with the pre-exercise condition. Glucose uptake during hyperinsulinaemia was increased in the leg (+31%, P less than 0.05), but not in the forearm. Basal lactate release by the leg was increased by the exercise, while lactate release by the forearm was decreased, significantly only during the clamp. These results indicate that local and not systemic factors are responsible for the changes in insulin sensitivity observed in the recovery from physical exercise.
G Annuzzi; G Riccardi; B Capaldo; L Kaijser
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of clinical investigation     Volume:  21     ISSN:  0014-2972     ISO Abbreviation:  Eur. J. Clin. Invest.     Publication Date:  1991 Feb 
Date Detail:
Created Date:  1991-09-11     Completed Date:  1991-09-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0245331     Medline TA:  Eur J Clin Invest     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  6-12     Citation Subset:  IM; S    
King Gustaf V Research Institute, Department of Clinical Physiology, Karolinska Hospital, Karolinska Institute, Stockholm, Sweden.
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MeSH Terms
Biological Transport, Active
Blood Glucose / metabolism
Exercise / physiology*
Glucose / metabolism*
Insulin / blood,  metabolism*
Insulin Resistance
Lactates / blood,  metabolism
Lactic Acid
Muscles / metabolism*
Reg. No./Substance:
0/Blood Glucose; 0/Lactates; 11061-68-0/Insulin; 50-21-5/Lactic Acid; 50-99-7/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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