Document Detail


Increased insulin receptor binding in erythrocytes from growth hormone-deficient children.
MedLine Citation:
PMID:  1760528     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Erythrocytes from growth hormone-deficient children (GHd-children) (n = 10) showed a statistically significant increase in insulin binding at low unlabeled insulin concentrations, together with a threefold decrease in apparent receptor affinity, as compared to control children (C) (n = 11). Scatchard analysis of the binding data using the two-site model revealed that both the receptor concentration R1 [GHd-children 0.10 +/- 0.01 ng/ml and C 0.03 +/- 0.002 ng/ml] and the dissociation constant KD1 [GHd-children (0.48 +/- 0.05) x 10(-9) M and C (0.19 +/- 0.01) x 10(-9) M] for high affinity-low capacity sites were significantly increased in erythrocytes from GHd-children, while neither receptor concentrations (R2) nor the dissociation constant (KD2) for low affinity-high capacity sites proved to be altered. These events were accompanied by a normal sensitivity to insulin as well as glucose tolerance in the GHd-group. The meaning of the increased insulin binding with normal insulin sensitivity in GH-deficiency is discussed.
Authors:
N Dávila; B Barceló; M C Carranza; C Calle
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Bioscience reports     Volume:  11     ISSN:  0144-8463     ISO Abbreviation:  Biosci. Rep.     Publication Date:  1991 Aug 
Date Detail:
Created Date:  1992-02-11     Completed Date:  1992-02-11     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8102797     Medline TA:  Biosci Rep     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  195-201     Citation Subset:  IM    
Affiliation:
Servicio de Endocrinología, Universidad Autónoma de Madrid, Spain.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Child
Child, Preschool
Erythrocytes / metabolism*
Female
Glucose Tolerance Test
Growth Hormone / deficiency*
Humans
Insulin / metabolism
Insulin Resistance
Male
Receptor, Insulin / metabolism*
Chemical
Reg. No./Substance:
11061-68-0/Insulin; 9002-72-6/Growth Hormone; EC 2.7.10.1/Receptor, Insulin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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