Document Detail


Increased indexes of thrombin activation in advanced stages of hypertension.
MedLine Citation:
PMID:  11408749     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The hemostatic system plays an important role in thrombotic lesions, which can complicate the clinical course of hypertensive patients. The aim of this study was to verify a possible activation of the blood clotting processes, the evaluation of two markers of thrombin activation in 62 hypertensive patients, with and without vascular complications, compared with a control group. METHODS AND RESULTS: In 22 patients with newly diagnosed uncomplicated essential hypertension, in 40 hypertensive patients with clinically evident vascular complications (20 patients with controlled blood pressure and 20 with uncontrolled and high blood pressure) and in 20 normotensive sex- and age-matched subjects, two indexes of thrombin generation and action, namely prothrombin fragment 1 + 2 (F1 + 2) and fibrinopeptide A (FPA) were evaluated. The observed values show an increase of the F1 + 2 levels in patients with overt vascular complications; those with higher blood pressure, moreover, showed FPA levels higher than those with controlled blood pressure. CONCLUSIONS: These results seem to indicate that plasma F1 + 2 levels are significantly elevated, as a marker of a thrombosis-prone status, in patients with organic damage. Successively, with progress of hypertension and increasing blood pressure, the evidence of elevated FPA levels seems to indicate a clear prethrombotic situation which could turn into a thrombotic state.
Authors:
A Trifiletti; R Scamardi; M A Pizzoleo; G Sottilotta; N Barbera; N Frisina
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Haemostasis     Volume:  31     ISSN:  0301-0147     ISO Abbreviation:  Haemostasis     Publication Date:    2001 Jan-Feb
Date Detail:
Created Date:  2001-06-15     Completed Date:  2001-09-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0371574     Medline TA:  Haemostasis     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  49-54     Citation Subset:  IM    
Copyright Information:
Copyright 2001 S. Karger AG, Basel
Affiliation:
Department of Internal Medicine, University of Messina, Italy. atrifiletti@tin.it
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Biological Markers / blood
Cardiovascular Diseases / etiology
Disease Progression
Female
Fibrinopeptide A / metabolism
Humans
Hypertension / blood*,  complications*
Male
Matched-Pair Analysis
Middle Aged
Peptide Fragments / blood
Prothrombin
Severity of Illness Index
Thrombin / metabolism*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Peptide Fragments; 0/prothrombin fragment 1.2; 25422-31-5/Fibrinopeptide A; 9001-26-7/Prothrombin; EC 3.4.21.5/Thrombin

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