Document Detail


Increased incorporation of 14C-palmitate into tissue lipids by isolated heart myocytes in endotoxic shock.
MedLine Citation:
PMID:  6753537     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The incorporation of 14C-palmitate into various classes of tissue lipids by isolated adult dog heart myocytes was studied in an attempt to understand the pathophysiology of myocardial dysfunction during endotoxic shock. The results showed that the incorporation of 14C-palmitate into phospholipids was increased by 85.3% and 108.8% at 0.5 hours and two hours, respectively, following endotoxin (0.5 mg Escherichia coli lipopolysaccharide B per kg body weight) administration. Incorporation of radioactive palmitate into triglycerides was increased by 50.9% and 107.2% at 0.5 and two hours, respectively, postendotoxin. Incorporation of 14C-palmitate into diglycerides was stimulated by 51.9% and 64.5% at 0.5 and two hours, respectively, after endotoxin injection. The incorporation of 14C-palmitate into tissue-free fatty acids and unaltered at 0.5 hours but it was increased by 211.7% at two hours postendotoxin. These data demonstrated that myocardial membrane lipid profile was greatly altered by increased incorporation of 14C-palmitate into phospholipids and neutral lipids after endotoxin administration. An alteration in myocardial lipid profile, as reported in this study, may contribute to the development of myocardial dysfunction during shock.
Authors:
M S Liu
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Advances in shock research     Volume:  7     ISSN:  0195-878X     ISO Abbreviation:  Adv Shock Res     Publication Date:  1982  
Date Detail:
Created Date:  1982-12-16     Completed Date:  1982-12-16     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7908298     Medline TA:  Adv Shock Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  43-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acyl Coenzyme A / metabolism
Animals
Carbon Radioisotopes / diagnostic use
Diglycerides / biosynthesis
Dogs
Endotoxins / pharmacology
Escherichia coli
Fatty Acids, Nonesterified / biosynthesis
Female
Lipids / biosynthesis*
Male
Myocardium / metabolism*
Palmitates / metabolism*
Palmitic Acids / metabolism*
Phospholipids / biosynthesis
Shock, Septic / metabolism*
Triglycerides / biosynthesis
Grant Support
ID/Acronym/Agency:
AM-25270/AM/NIADDK NIH HHS; GM-26790/GM/NIGMS NIH HHS; HL-23618/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Acyl Coenzyme A; 0/Carbon Radioisotopes; 0/Diglycerides; 0/Endotoxins; 0/Fatty Acids, Nonesterified; 0/Lipids; 0/Palmitates; 0/Palmitic Acids; 0/Phospholipids; 0/Triglycerides

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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