Document Detail

Increased incidence of thrombophilic abnormalities in patients with cranial dural arteriovenous fistulae.
MedLine Citation:
PMID:  14579793     Owner:  NLM     Status:  MEDLINE    
Cranial dural arteriovenous fistulae (DAVF) may occur post-traumatic or sporadic. The physiopathologic mechanisms of sporadic DAVF are still unclear. A dural sinus thrombosis followed by an increase in venous pressure and/or an increased procoagulatory activity of the coagulation system are associated at least with some DAVF. The objective of this study was to investigate the coagulation profile in patients with DAVF. Thus the association of thrombophilic abnormalities, sinus thrombosis and DAVF should be analyzed. A total of 15 patients with cranial DAVF were included in this study. Blood samples were analyzed for 20210A mutation of the prothrombin gene, resistance to activated protein C and factor V Leiden mutation. Fibrinogen (Fib), Textarin time (TT), antithrombin (AT), protein C and protein S activity, von Willebrand factor antigen (vWF:Ag), Ristocetin cofactor activity (vWF:RCo), D-Dimer (DD) and coagulation factor VIII-activity (F VIII) were determined in all patients. Blood was screened for the occurrence of lupus antiphospholipid antibodies and cardiolipin antibodies. Thrombophilic risk factors were found in 5 (33%) of the 15 patients with cranial DAVF. Four patients had a heterozygote 20210A mutation of the prothrombin gene and one patient had a heterozygote FV Leiden mutation. Sinus thrombosis was detected in two patients with grade 2b DAVF and was associated with a 20210A mutation of the prothrombin gene in both patients. Additionally, one patient had deficient protein C activity and screening for cardiolipin antibodies was positive in three patients. In the current series the frequency of prothrombin Gene 20210A mutation was higher in patients with DAVF compared to the general population, whereas the incidence of Factor V Leiden mutation was not. Therefore in patients with cranial DAVF thrombophilic abnormalities should be considered in the post-operative/post-interventional management.
Rüdiger Gerlach; Hilal Yahya; Stefan Rohde; Martina Böhm; Joachim Berkefeld; Inge Scharrer; Volker Seifert; Andreas Raabe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurological research     Volume:  25     ISSN:  0161-6412     ISO Abbreviation:  Neurol. Res.     Publication Date:  2003 Oct 
Date Detail:
Created Date:  2003-10-28     Completed Date:  2003-12-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7905298     Medline TA:  Neurol Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  745-8     Citation Subset:  IM    
Department of Neurosurgery, Johann Wolfgang Goethe-University, Schleusenweg 2-16, 60528 Frankfurt/Main, Germany.
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MeSH Terms
Central Nervous System Vascular Malformations / complications*,  genetics*
Middle Aged
Risk Factors
Sinus Thrombosis, Intracranial / complications*,  genetics*

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