Document Detail

Increased incidence of stent thrombosis in patients with cocaine use.
MedLine Citation:
PMID:  17492789     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Coronary stent thrombosis is a rare occurrence in the era of dual-antiplatelet therapy. It is not known whether patients who use cocaine have a higher risk of thrombosis following coronary stent placement. METHODS: We studied 247 consecutive patients who underwent coronary stent placement at an inner-city hospital. RESULTS: Twelve patients (4.9%) were actively using cocaine at the time of PCI. Of these twelve patients, four patients presented with stent thrombosis (33%) at a mean of 51 +/- 40 days (median 45 days), after the index revascularization procedure. Only 2 of the 235 patients without documented cocaine use (0.85%) had stent thrombosis during the same period (P < 0.0001). CONCLUSION: The patients who actively use cocaine have a markedly higher risk of stent thrombosis when compared with patients without a documented history of cocaine use. We discuss various factors that potentially predispose cocaine users to stent thrombosis.
Gudjon Karlsson; Jalees Rehman; Vijay Kalaria; Jeffrey A Breall
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions     Volume:  69     ISSN:  1522-1946     ISO Abbreviation:  Catheter Cardiovasc Interv     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-31     Completed Date:  2007-07-13     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100884139     Medline TA:  Catheter Cardiovasc Interv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  955-8     Citation Subset:  IM    
Cardiac Catheterization Laboratories, Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
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MeSH Terms
Angina Pectoris / etiology,  prevention & control
Angioplasty, Transluminal, Percutaneous Coronary / adverse effects*
Aspirin / therapeutic use
Cocaine-Related Disorders / complications*
Coronary Angiography
Coronary Artery Disease / complications,  drug therapy,  radiography,  therapy*
Coronary Thrombosis / complications,  etiology*,  prevention & control,  radiography
Drug Therapy, Combination
Follow-Up Studies
Hospitals, Urban / statistics & numerical data
Middle Aged
Myocardial Infarction / etiology,  prevention & control
Platelet Aggregation Inhibitors / therapeutic use*
Research Design
Retrospective Studies
Risk Assessment
Risk Factors
Ticlopidine / analogs & derivatives,  therapeutic use
Time Factors
Treatment Outcome
United States
Reg. No./Substance:
0/Platelet Aggregation Inhibitors; 50-78-2/Aspirin; 55142-85-3/Ticlopidine; 90055-48-4/clopidogrel
Comment In:
Catheter Cardiovasc Interv. 2007 Jun 1;69(7):959-60   [PMID:  17525956 ]

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