| Increased incidence of stent thrombosis in patients with cocaine use. | |
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MedLine Citation:
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PMID: 17492789 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Coronary stent thrombosis is a rare occurrence in the era of dual-antiplatelet therapy. It is not known whether patients who use cocaine have a higher risk of thrombosis following coronary stent placement. METHODS: We studied 247 consecutive patients who underwent coronary stent placement at an inner-city hospital. RESULTS: Twelve patients (4.9%) were actively using cocaine at the time of PCI. Of these twelve patients, four patients presented with stent thrombosis (33%) at a mean of 51 +/- 40 days (median 45 days), after the index revascularization procedure. Only 2 of the 235 patients without documented cocaine use (0.85%) had stent thrombosis during the same period (P < 0.0001). CONCLUSION: The patients who actively use cocaine have a markedly higher risk of stent thrombosis when compared with patients without a documented history of cocaine use. We discuss various factors that potentially predispose cocaine users to stent thrombosis. |
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Authors:
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Gudjon Karlsson; Jalees Rehman; Vijay Kalaria; Jeffrey A Breall |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article |
Journal Detail:
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Title: Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions Volume: 69 ISSN: 1522-1946 ISO Abbreviation: Catheter Cardiovasc Interv Publication Date: 2007 Jun |
Date Detail:
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Created Date: 2007-05-31 Completed Date: 2007-07-13 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100884139 Medline TA: Catheter Cardiovasc Interv Country: United States |
Other Details:
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Languages: eng Pagination: 955-8 Citation Subset: IM |
Affiliation:
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Cardiac Catheterization Laboratories, Krannert Institute of Cardiology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angina Pectoris
/
etiology,
prevention & control Angioplasty, Transluminal, Percutaneous Coronary / adverse effects* Aspirin / therapeutic use Cocaine-Related Disorders / complications* Coronary Angiography Coronary Artery Disease / complications, drug therapy, radiography, therapy* Coronary Thrombosis / complications, etiology*, prevention & control, radiography Drug Therapy, Combination Follow-Up Studies Hospitals, Urban / statistics & numerical data Humans Middle Aged Myocardial Infarction / etiology, prevention & control Platelet Aggregation Inhibitors / therapeutic use* Research Design Retrospective Studies Risk Assessment Risk Factors Stents* Ticlopidine / analogs & derivatives, therapeutic use Time Factors Treatment Outcome United States |
| Chemical | |
Reg. No./Substance:
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0/Platelet Aggregation Inhibitors; 50-78-2/Aspirin; 55142-85-3/Ticlopidine; 90055-48-4/clopidogrel |
| Comments/Corrections | |
Comment In:
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Catheter Cardiovasc Interv. 2007 Jun 1;69(7):959-60
[PMID:
17525956
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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