Document Detail

Increased incidence of sepsis at birth in neutropenic infants of mothers with preeclampsia.
MedLine Citation:
PMID:  8071757     Owner:  NLM     Status:  MEDLINE    
Neutropenia is often found at birth in infants born to mothers with preeclampsia, and is most likely present in utero. To determine whether this neutropenia is associated with an increased incidence of early-onset sepsis, we reviewed the hospital records of 301 low birth weight infants of mothers with preeclampsia. Early-onset sepsis was proved if the result of a culture of blood or cerebrospinal fluid in the first 48 hours of life was positive, or presumed if culture results were negative but two or more clinical signs of sepsis were present and the attending neonatologist believed that an infant was infected and needed at least 7 days of antibiotic therapy. Forty-eight percent of low birth weight infants of mothers with preeclampsia had neutropenia at less than 12 hours of age. Infants with neutropenia had mothers with more severe preeclampsia, were more premature (30 weeks vs 32 weeks), weighed less (1097 gm vs 1615 gm), and were more likely to be small for gestational age. Although maternal and obstetric risk factors for infection were less common in the group with neutropenia, rates of proven or presumed early-onset sepsis were higher (14% vs 2%; p < 0.001). Sepsis was proved in 6% of infants with neutropenia and in none of the infants without neutropenia (p = 0.03). A logistic regression analysis of the relative effects of birth weight, gestational age, and absolute neutrophil count on the incidence of sepsis revealed that only a low absolute neutrophil count correlated significantly with an increased risk of early-onset sepsis in infants with neutropenia.
M W Doron; R A Makhlouf; V L Katz; E E Lawson; A D Stiles
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of pediatrics     Volume:  125     ISSN:  0022-3476     ISO Abbreviation:  J. Pediatr.     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1994-09-29     Completed Date:  1994-09-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  452-8     Citation Subset:  AIM; IM    
Department of Pediatrics, University of North Carolina Hospitals, University of North Carolina at Chapel Hill 27599-7596.
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MeSH Terms
Bacterial Infections / complications*
Cause of Death
Chorioamnionitis / complications
Cohort Studies
Fetal Membranes, Premature Rupture / complications
HELLP Syndrome
Infant, Low Birth Weight*
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / blood
Infant, Small for Gestational Age
Leukocyte Count
Neutropenia / blood,  congenital*
Retrospective Studies
Survival Rate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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