| Increased incidence of sepsis at birth in neutropenic infants of mothers with preeclampsia. | |
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MedLine Citation:
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PMID: 8071757 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neutropenia is often found at birth in infants born to mothers with preeclampsia, and is most likely present in utero. To determine whether this neutropenia is associated with an increased incidence of early-onset sepsis, we reviewed the hospital records of 301 low birth weight infants of mothers with preeclampsia. Early-onset sepsis was proved if the result of a culture of blood or cerebrospinal fluid in the first 48 hours of life was positive, or presumed if culture results were negative but two or more clinical signs of sepsis were present and the attending neonatologist believed that an infant was infected and needed at least 7 days of antibiotic therapy. Forty-eight percent of low birth weight infants of mothers with preeclampsia had neutropenia at less than 12 hours of age. Infants with neutropenia had mothers with more severe preeclampsia, were more premature (30 weeks vs 32 weeks), weighed less (1097 gm vs 1615 gm), and were more likely to be small for gestational age. Although maternal and obstetric risk factors for infection were less common in the group with neutropenia, rates of proven or presumed early-onset sepsis were higher (14% vs 2%; p < 0.001). Sepsis was proved in 6% of infants with neutropenia and in none of the infants without neutropenia (p = 0.03). A logistic regression analysis of the relative effects of birth weight, gestational age, and absolute neutrophil count on the incidence of sepsis revealed that only a low absolute neutrophil count correlated significantly with an increased risk of early-onset sepsis in infants with neutropenia. |
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Authors:
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M W Doron; R A Makhlouf; V L Katz; E E Lawson; A D Stiles |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of pediatrics Volume: 125 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 1994 Sep |
Date Detail:
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Created Date: 1994-09-29 Completed Date: 1994-09-29 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 452-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, University of North Carolina Hospitals, University of North Carolina at Chapel Hill 27599-7596. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bacterial Infections
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complications* Cause of Death Chorioamnionitis / complications Cohort Studies Female Fetal Membranes, Premature Rupture / complications HELLP Syndrome Humans Incidence Infant, Low Birth Weight* Infant, Newborn Infant, Premature Infant, Premature, Diseases / blood Infant, Small for Gestational Age Leukocyte Count Neutropenia / blood, congenital* Pre-Eclampsia* Pregnancy Retrospective Studies Survival Rate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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