| Increased incidence of interstitial pneumonia by CHOP combined with rituximab. | |
| | |
MedLine Citation:
|
PMID: 18409079 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Several authors have reported interstitial pneumonia (IP) during rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) therapy, while others have encountered Pneumocystis jirovecii pneumonia during rituximab-combined bi-weekly CHOP. Herein, we report that 13 of 90 (14%) patients developed IP during R-CHOP therapy, compared with none of 105 patients treated with CHOP alone as a historical control. There were no differences in baseline data between patients undergoing the two therapies. Among R-CHOP-treated patients, serum beta-D-glucan was increased in 8 of 12 (75%) IP patients compared with none of 30 non-IP patients examined. In five IP patients who underwent sputum evaluation, two were positive for P. jirovecii by the polymerase chain reaction and another two were positive for Candida albicans. No other organisms were detected as causative pathogens. Treatment with steroids, sulfamethoxazole-trimethoprim (ST), and antifungals was effective. Our results suggest that R-CHOP raises the incidence of IP, possibly through increasing the susceptibility to P. jirovecii and fungal infection. The need for prophylactic antifungals and ST during R-CHOP should be evaluated by randomized controlled trials. |
| | |
Authors:
|
Daisuke Ennishi; Yasuhito Terui; Masahiro Yokoyama; Yuko Mishima; Shunji Takahashi; Kengo Takeuchi; Kazuma Ikeda; Mitsune Tanimoto; Kiyohiko Hatake |
Related Documents
:
|
7831539 - Community-acquired pneumonia: the future of the microbiology laboratory: focused diagno... 15906659 - Prevalence and clinical features of chlamydia pneumoniae pneumonia at srinagarind hospi... 2327729 - Low levels of unsaturated transferrin as a predictor of survival in pneumococcal pneumo... 19512939 - Bacterial meningitis in hiv-1-infected patients in the era of highly active antiretrovi... 19911359 - Pediatric parapneumonic pleural effusion: epidemiology, clinical characteristics, and m... 11964919 - Community-acquired pneumonia: process of care studies. 3808129 - Antiimmunoglobulins of rheumatoid factor (rf) type in prediction of melanoma patients. 19283229 - Overcoming communication barriers - working with patients with intellectual disabilities. 20028329 - Rapid sequence intubation: a review of recent evidences. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: International journal of hematology Volume: 87 ISSN: 0925-5710 ISO Abbreviation: Int. J. Hematol. Publication Date: 2008 May |
Date Detail:
|
Created Date: 2008-10-30 Completed Date: 2009-04-15 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9111627 Medline TA: Int J Hematol Country: United States |
Other Details:
|
Languages: eng Pagination: 393-7 Citation Subset: IM |
Affiliation:
|
Department of Oncology and Hematology, Cancer Institute Hospital, 3-10-6 Ariake, Koto-ku, Tokyo 135-8550, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Antibodies, Monoclonal / therapeutic use* Antineoplastic Combined Chemotherapy Protocols / therapeutic use* Biochemistry Cyclophosphamide / therapeutic use Doxorubicin / therapeutic use Female Humans Immunotherapy Lung Diseases, Interstitial / metabolism, pathology* Lymphoma / drug therapy, immunology Male Middle Aged Prednisone / therapeutic use Vincristine / therapeutic use |
| Chemical | |
Reg. No./Substance:
|
0/Antibodies, Monoclonal; 0/CHOP protocol; 0/rituximab; 23214-92-8/Doxorubicin; 50-18-0/Cyclophosphamide; 53-03-2/Prednisone; 57-22-7/Vincristine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Primary non-Hodgkin lymphomas in the small and large intestine: clinicopathological characteristics ...
Next Document: Reserpine can confer stress tolerance and lifespan extension in the nematode C. elegans.