| Increased incidence of disseminated histoplasmosis following highly active antiretroviral therapy initiation. | |
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MedLine Citation:
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PMID: 16652055 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To determine whether the initiation of highly active antiretroviral therapy (HAART) had any influence on the incidence of disseminated histoplasmosis, a retrospective cohort study was performed on 1551 patients followed for up to 12 years. After controlling for CD4 counts, age, and sex, patients taking HAART for 2 months or less were more likely to develop disseminated histoplasmosis than untreated patients (respectively, hazard ratio, 3.7 [95% confidence interval, 1.57-8.7]; P = 0.003). In contrast, after 6 months of HAART, treated patients were less likely to develop disseminated histoplasmosis than untreated patients (hazard ratio, 0.6 [95% confidence interval, 0.37-0.98], P = 0.04). This increased incidence suggests that the initiation of HAART and the subsequent immune reconstitution may reveal undiagnosed latent disseminated histoplasmosis. |
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Authors:
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Mathieu Nacher; Frédérique Sarazin; Myriam El Guedj; Tania Vaz; Fernand Alvarez; Valery Nasser; Andry Randrianjohany; Christine Aznar; Bernard Carme; Pierre Couppié |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of acquired immune deficiency syndromes (1999) Volume: 41 ISSN: 1525-4135 ISO Abbreviation: J. Acquir. Immune Defic. Syndr. Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-05-02 Completed Date: 2006-06-06 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100892005 Medline TA: J Acquir Immune Defic Syndr Country: United States |
Other Details:
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Languages: eng Pagination: 468-70 Citation Subset: IM; X |
Affiliation:
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CISIH, Cayenne General Hospital, French Guiana. m_nacher@lycos.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antiretroviral Therapy, Highly Active* Cohort Studies HIV Infections / complications*, drug therapy* Histoplasmosis / epidemiology* Humans Incidence Retrospective Studies Statistics as Topic Time Factors |
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