| Increased incidence of cytomegalovirus disease after autologous CD34-selected peripheral blood stem cell transplantation. | |
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MedLine Citation:
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PMID: 10590046 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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High-dose therapy with autologous peripheral blood stem cell (PBSC) rescue is widely used for the treatment of malignant disease. CD34 selection of PBSC has been applied as a means of reducing contamination of the graft. Although CD34 selection results in a 2 to 3 log reduction in contaminating tumor cells without significantly delaying engraftment, many other types of cells are depleted from the CD34-enriched grafts and immune reconstitution may be impaired. In the present study, 31 cytomegalovirus (CMV)-seropositive patients who received myeloablative therapy followed by the infusion of CD34-selected autologous PBSC were assessed for the development of CMV disease in the first 100 days posttransplant. Seven patients (22.6%) developed CMV disease and 4 patients (12.9%) died from complications of their infection. In a contemporaneous group of 237 CMV-seropositive patients receiving unselected, autologous PBSC, only 10 patients (4.2%) developed CMV disease, with 5 deaths (2.1%). In a multivariate logistic regression analysis, the use of CD34-selected autologous PBSC after high-dose therapy was associated with a marked increase in the incidence of CMV disease and CMV-associated deaths. |
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Authors:
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L A Holmberg; M Boeckh; H Hooper; W Leisenring; S Rowley; S Heimfeld; O Press; D G Maloney; P McSweeney; L Corey; R T Maziarz; F R Appelbaum; W Bensinger |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Blood Volume: 94 ISSN: 0006-4971 ISO Abbreviation: Blood Publication Date: 1999 Dec |
Date Detail:
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Created Date: 2000-01-10 Completed Date: 2000-01-10 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7603509 Medline TA: Blood Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 4029-35 Citation Subset: AIM; IM |
Affiliation:
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Clinical Division, Fred Hutchinson Cancer Research Center, Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Antigens, CD34 Autoimmune Diseases / therapy* Child Child, Preschool Cytomegalovirus / isolation & purification* Cytomegalovirus Infections / etiology* Female Graft Survival Hematopoietic Stem Cell Transplantation / adverse effects* Humans Male Middle Aged Neoplasms / therapy* Transplantation, Autologous / adverse effects |
| Grant Support | |
ID/Acronym/Agency:
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CA18029/CA/NCI NIH HHS; CA18221/CA/NCI NIH HHS; CA47748/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD34 |
| Comments/Corrections | |
Comment In:
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Blood. 2001 Apr 1;97(7):2183-5
[PMID:
11286223
]
Blood. 2000 Aug 1;96(3):1194 [PMID: 10960239 ] Blood. 2000 Jun 15;95(12):4016-8 [PMID: 10939798 ] Blood. 2000 Jul 1;96(1):369-70 [PMID: 10939802 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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